Drug Interaction Study Between Rifabutin And Lersivirine (UK-453,061) - NCT00925535-06511 (Clinical Trial 299069)
Permalink: http://www.ClinicalConnection.com/exp/ExpandedPatientViewStudy299069.aspx
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| City: |
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New Haven |
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State:
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CT |
| Zip Code: |
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06511 |
| Conditions: |
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Healthy Volunteers |
| Purpose: |
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Approximately 1/3 of persons living with HIV infection are co-infected with tuberculosis
(TB). Rifabutin, used in the treatment of TB, is an inducer of drug metabolism thus may
decrease concentrations of lersivirine if co-administered. Lersivirine is a modest inducer
of drug metabolism, thus lersivirine may decrease concentrations of rifabutin as well.
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| Study summary: |
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| Criteria: |
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Inclusion Criteria:
- Healthy male and/or female subjects between the ages of 18 and 55 years, inclusive.
- Body Mass Index (BMI) of 17.5 to 30.5 kg/m2; and a total body weight >50 kg (110
lbs).
Exclusion Criteria:
- Evidence or history of clinically significant hematological, renal, endocrine,
pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, neurologic, or
allergic disease.
- History of regular alcohol consumption exceeding 7 drinks/week for women and 14
drinks/week for men (1 drink = 150 mL of wine or 360 mL of beer or 45 mL of hard
liquor).
- Use of tobacco- or nicotine-containing products in excess of the equivalent of 5
cigarettes per day.
- Hypersensitivity/allergic reactions to any component of the study drugs. |
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If you are interested in this clinical trial please use the contact information above. If you would like to get additional information about this clinical trial please visit ClinicalTrials.gov.
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| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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February 2, 2010 |
Modifications to
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Only selected fields are shown, please use the link
above to view all information about this clinical trial. |
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Clinical trials are medical research studies designed to test the safety and/or
effectiveness of new drugs, devices, or treatments in humans. These studies are
conducted worldwide for a range of conditions and illnesses. Learn more about
clinical research and participating in a study at
About Clinical Trials.
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