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View Clinical Trial (Medical Research Study)
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Effects of Teriparatide or Zoledronic Acid Treatment on Bone in Postmenopausal Osteoporotic Women - NCT00927186-53705 (Clinical Trial 299438)
Permalink: http://www.ClinicalConnection.com/exp/ExpandedPatientViewStudy299438.aspx
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| City: |
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Madison |
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State:
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WI |
| Zip Code: |
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53705 |
| Conditions: |
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Osteoporosis, Post-Menopausal |
| Purpose: |
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The purpose of this study is to investigate how teriparatide or zoledronic acid affects the
bone of postmenopausal osteoporotic women after 6 months of treatment as determined by a
bone biopsy sample taken from the iliac crest (upper part of the pelvis).
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| Study summary: |
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| Criteria: |
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Inclusion Criteria:
- Ambulatory, postmenopausal women with osteoporosis (no vaginal bleeding for at least
2 years prior to trial entry)
- Free of severe or chronically disabling conditions other than osteoporosis that will
impair ability to complete the trial
- Bone mineral density (BMD) T-score of at least -2.5 at the femoral neck, total hip,
or lumbar spine (L1-L4, with at least 2 evaluable vertebrae), with or without
atraumatic fracture or,
- Bone mineral density (BMD) T-score of at least -1.5 at the femoral neck, or total
hip, or lumbar spine (L1-L4, with at least 2 evaluable vertebrae), and either 1 or
more atraumatic vertebral fracture(s) or an atraumatic nonvertebral fracture in the
opinion of the investigator. Nonvertebral fracture sites allowed are wrist, hip,
pelvis, ribs,humerus,clavicle, leg (femur, tibia, and fibula, excluding the ankle).
- Serum calcium, PTH, alkaline phosphatase must be within normal reference range
Exclusion Criteria:
- Have an increased risk of osteosarcoma (bone tumor); this includes Paget's disease of
bone, a previous bone tumor, or radiation involving the skeleton
- Are allergic or cannot tolerate teriparatide or zoledronic acid or any of their
ingredients or components
- Are allergic to tetracycline
- Have a history of exposure to tetracycline therapy in the 3 months prior to trial
entry
- Have participated in a prior parathyroid hormone (PTH) clinical trial or received
prior treatment with teriparatide, PTH, or other related medications
- Have a vitamin D level below 10 ng/ml
- Have a condition that could possibly put one at risk for an adverse event due to the
bone biopsy procedure (e.g. bleeding disorder)
- Have undergone two previous iliac crest bone biopsies (one in each iliac crest)
- Have taken any intravenous (IV) osteoporosis medication
- Have taken other oral osteoporosis medications and have not been off of them for a
specific period of time before trial entry
- Have a history of certain cancers in the 5 years prior to trial entry
- Have active liver disease
- Have significantly impaired kidney function
- Currently have active or suspected diseases that affect the bones, other than
osteoporosis
- Have active or recent history of significant gastrointestinal (stomach or intestinal)
disorders
- Have been treated with certain glucocorticoids for more than 30 days in the past 1
year prior to trial entry |
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| Study is available at: |
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For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
Madison, WI 53705
United States
Primary Contact:
There may be multiple sites in this clinical trial 1-877-CTLILLY (1-877-285-4559) or
Phone: 1-317-615-4559 |
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If you are interested in this clinical trial please use the contact information above. If you would like to get additional information about this clinical trial please visit ClinicalTrials.gov.
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| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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March 16, 2010 |
Modifications to
this listing: |
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Only selected fields are shown, please use the link
above to view all information about this clinical trial. |
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Clinical trials are medical research studies designed to test the safety and/or
effectiveness of new drugs, devices, or treatments in humans. These studies are
conducted worldwide for a range of conditions and illnesses. Learn more about
clinical research and participating in a study at
About Clinical Trials.
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