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Trial Comparing Neomycin to Rifaximin Plus Neomycin in the Treatment of Methane Positive Subjects With Constipation Predominant Irritable Bowel Syndrome (C-IBS) - NCT00945334-90048(Clinical Trial 303198)



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City:  Los Angeles
State:  
CA
Zip Code: 90048
Conditions: Irritable Bowel Syndrome Characterized by Constipation
Purpose: In this study the investigators aim to compare the efficacy of neomycin to a combination of rifaximin and neomycin in the treatment of C-IBS subjects with methane on their breath test. This study will be conducted in collaboration with Dr. John DiBaise at the Mayo Clinic in Scottsdale, AZ.
Study summary:
Criteria: Inclusion Criteria: - Rome III positive IBS subjects (18-75 years of age) -Meet criteria for constipation predominant IBS symptoms including ≤ 3 bm per week with hard or lumpy stools. - Presence of detectable methane on single breath sample (≥ 3ppm). - If subjects are ≥ 50 years old, a colonoscopy had to have been completed within the past 5 years. Exclusion Criteria: - Subjects with history of intestinal surgery (except appendectomy or cholecystectomy) - Recent antibiotic use (within the last 30 days) - Subjects with known pelvic floor dysfunction - Pregnancy - Creatinine level > 1.4 - Poorly controlled/uncontrolled significant medical condition that would interfere with study procedures - Subjects with hearing loss and/or tinnitus - History of bowel obstruction - History of celiac disease - History of inflammatory bowel disease - Cirrhosis - Diabetes
Study is available at: Cedars-Sinai Medical Center
Los Angeles, CA 90048
United States

Primary Contact:
Kathleen Shari Chua, BA
Email: Chuak@cshs.org
Phone: 310-423-3792

Secondary Contact:
Kathleen Shari Chua, BA
Email: Chuak@cshs.org
Phone: (310)423-3792
If you are interested in this clinical trial please use the contact information above. If you would like to get additional information about this clinical trial please visit ClinicalTrials.gov.
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Data Source: ClinicalTrials.gov
Date Processed: March 23, 2011
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