A Study To Evaluate The Safety, Tolerability, Pharmacokinetics, And Pharmacodynamics Of PF-03882845 In Healthy Volunteers - NCT00971802-33143(Clinical Trial 319691)
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South Miami |
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State:
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FL |
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33143 |
| Conditions: |
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Healthy Volunteers |
| Purpose: |
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To evaluate the safety and tolerability of PF-03882845 in Healthy Volunteers. To evaluate
the pharmacokinetics of PF-03882845 in Healthy Volunteers. To evaluate the pharmacodynamics
of PF-03882845 in Healthy Volunteers.
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| Study summary: |
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| Criteria: |
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Inclusion Criteria:
- Body Mass Index (BMI) of 17.5 to 30.5 kg/m2; and a total body weight >50 kg (110
lbs).
- Subjects who are willing and able to comply with scheduled visits, treatment plan,
laboratory tests, and other study procedures.
Exclusion Criteria:
- Evidence or history of clinically significant disease.
- Past medical history of epididymitis, orchitis, sexually transmitted diseases
(chlamydia, gonorrhea, etc.) or urinary tract infection.
- History of prostatitis or prostate surgery.
- Urinary catheterization or instrumentation within 12 months of screening. Inguinal or
scrotal hernia.
- Current or history of congenital genital abnormalities.
- Baseline scrotal ultrasound scan showing unilateral or bilateral scrotal blood flow
abnormalities or anatomic abnormalities (hydrocele, cysts, other), with the exception
of small epididymal cysts and spermatoceles.
- Any condition possibly affecting drug absorption (eg, gastrectomy).
- Blood donation of approximately 1 pint (500 mL) within 56 days prior to dosing.
- History of sensitivity to spironolactone, eplerenone, or related compounds.
- Serum potassium >5.5 mEq/L at screening or Day 0. |
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If you are interested in this clinical trial please use the contact information above. If you would like to get additional information about this clinical trial please visit ClinicalTrials.gov.
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| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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February 17, 2010 |
Modifications to
this listing: |
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Only selected fields are shown, please use the link
above to view all information about this clinical trial. |
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