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Microparticles in Pediatric Inflammatory Disease - NCT00979485-46202(Clinical Trial 331490)



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City:  Indianapolis
State:  
IN
Zip Code: 46202
Conditions: Crohn's Disease - Ulcerative Colitis
Purpose: The purpose of this study is to provide data correlating levels of microparticles that circulate in the blood and disease activity in children with inflammatory bowel disease (IBD). The hypothesis is that circulating microparticles will be higher in children with active IBD, show inflammatory activity, and will be low in patients in remission as well as in healthy controls.
Study summary: Once the response of microparticles to inflammation is defined in this patient population, the microparticles can be used as biomarkers of disease activity and could potentially use microparticles as targets of therapeutic agents. This cross sectional study will enroll 15 Crohn's patients (5 inactive, 5 mild, 5 moderate-severe disease based on the pediatric Crohn's disease activity index), 15 Ulcerative Colitis patients (5 inactive, 5 mild, 5 moderate-severe disease based on the pediatric ulcerative colitis activity index), and 10 healthy controls.
Criteria: Inclusion Criteria: - Children with IBD based on endoscopic, histologic, radiologic, or laboratory data - Ages between 8 and 17 years old Exclusion Criteria: - Anyone with a concurrent illness since infection can affect microparticle levels
Study is available at: Indiana Unversity, Riley Hospital for Children
Indianapolis, IN 46202
United States

Primary Contact:
Trisha A Davis, RN
Email: tawilson@iupui.edu
Phone: 317-278-5858
If you are interested in this clinical trial please use the contact information above. If you would like to get additional information about this clinical trial please visit ClinicalTrials.gov.
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Data Source: ClinicalTrials.gov
Date Processed: March 23, 2011
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