View Clinical Trial (Medical Research Study)
Cigarette Smoke and Susceptibility to Influenza Infection - NCT00448617-27599(Clinical Trial 370943)
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Chapel Hill |
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State:
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NC |
| Zip Code: |
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27599 |
| Conditions: |
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Healthy |
| Purpose: |
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This study will be a descriptive comparison of the effects of live attenuated influenza
virus (FluMist) on nasal inflammation and oxidative stress in healthy young adults who are
not exposed to smoke vs smokers. It is hypothesized that passive exposure to second-hand
smoke (SHS) results in increased susceptibility to the effects of influenza virus in nasal
epithelium in humans and that these effects are mediated by SHS-induced oxidative stress
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| Study summary: |
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Epidemiologic evidence supports a significant relationship between passive cigarette smoke
exposure and increased risk for viral respiratory illnesses. Published and preliminary data
suggest that airborne pollutants including tobacco smoke increase susceptibility of
respiratory epithelium to infection with influenza A and that this effect is at least
partially mediated by oxidative stress. However, no studies have specifically looked at the
interaction between smoking and the effects of influenza virus in human volunteers. |
| Criteria: |
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Inclusion Criteria:
- age 18-35 years
- healthy nonsmoking who are rarely exposed to SHS OR smokers
Exclusion Criteria:
- pregnancy or nursing;
- history of egg allergy;
- aspirin therapy;
- asthma;
- immunodeficiency (HIV or other);
- on immunosuppressive drugs including corticosteroids;
- history of Guillain-Barre Syndrome;
- any chronic medical condition;
- febrile and/or respiratory illness within past 3 weeks prior to entry into study;
- prospective subjects with high baseline antibody titers against influenza will be
excluded because they may be less likely to develop viral replication with LAIV. |
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If you are interested in this clinical trial please use the contact information above. If you would like to get additional information about this clinical trial please visit ClinicalTrials.gov.
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| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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September 9, 2010 |
Modifications to
this listing: |
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above to view all information about this clinical trial. |
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