Cigarette Smoke and Susceptibility to Influenza Infection - NCT00448617-27599 (Clinical Trial 370943)


Welcome To Clinical Connection



Our clinical trials database is updated daily
Over 250,000 individuals are currently being connected to clinical trials by ClinicalConnection.com!


Trials Alerts	Trials Search
Health Forum	Health News
RSS	Intro
Clinics & Sponsors	Member Login

View Clinical Trial (Medical Research Study)

Cigarette Smoke and Susceptibility to Influenza Infection - NCT00448617-27599 (Clinical Trial 370943)
Permalink: http://www.ClinicalConnection.com/exp/ExpandedPatientViewStudy370943.aspx

** Please review additional "Nearby Studies" on right ----->

City:

Chapel Hill

State:

Zip Code:

27599

Conditions:

Healthy

Purpose:

This study will be a descriptive comparison of the effects of live attenuated influenza virus (FluMist) on nasal inflammation and oxidative stress in healthy young adults who are not exposed to smoke vs smokers. It is hypothesized that passive exposure to second-hand smoke (SHS) results in increased susceptibility to the effects of influenza virus in nasal epithelium in humans and that these effects are mediated by SHS-induced oxidative stress

Study summary:

Epidemiologic evidence supports a significant relationship between passive cigarette smoke exposure and increased risk for viral respiratory illnesses. Published and preliminary data suggest that airborne pollutants including tobacco smoke increase susceptibility of respiratory epithelium to infection with influenza A and that this effect is at least partially mediated by oxidative stress. However, no studies have specifically looked at the interaction between smoking and the effects of influenza virus in human volunteers.

Criteria:

Inclusion Criteria: - age 18-35 years - healthy nonsmoking who are rarely exposed to SHS OR smokers Exclusion Criteria: - pregnancy or nursing; - history of egg allergy; - aspirin therapy; - asthma; - immunodeficiency (HIV or other); - on immunosuppressive drugs including corticosteroids; - history of Guillain-Barre Syndrome; - any chronic medical condition; - febrile and/or respiratory illness within past 3 weeks prior to entry into study; - prospective subjects with high baseline antibody titers against influenza will be excluded because they may be less likely to develop viral replication with LAIV.

Study is available at:

UNC Center for Environmental Medicine, Asthma and Lung Biology
Chapel Hill, NC 27599
United States

Primary Contact:
Margaret H Herbst, RN, MSN
Email: margaret_herbst@med.unc.edu
Phone: 919-966-2879

If you are interested in this clinical trial please use the contact information above. If you would like to get additional information about this clinical trial please visit ClinicalTrials.gov.

Trials Alerts:

If you would like to be notified of new clinical trials as they become available please register for a free account.

Data Source:		ClinicalTrials.gov
Date Processed:		February 16, 2010
Modifications to this listing:		Only selected fields are shown, please use the link above to view all information about this clinical trial.

Clinical trials are medical research studies designed to test the safety and/or effectiveness of new drugs, devices, or treatments in humans. These studies are conducted worldwide for a range of conditions and illnesses. Learn more about clinical research and participating in a study at About Clinical Trials.


Featured Nearby Studies:

Within 25 Miles

Smoking - Durham NC

Osteoporosis in Females Over 65 Not Taking Hormone Therapy - Durham NC

Smoking - Durham NC

Diabetic Gastroparesis - Raleigh NC

Hypo-Sexual Desire Disorder (HSDD) - Raleigh NC

Acne - Raleigh NC

Smoking Cessation - Raleigh NC

Diabetic Gastroparesis - Raleigh NC

Alzheimer's Disease - Raleigh NC

Bone Density Study for Young Women Aged 12 to 18 - Raleigh NC

Heartburn - Raleigh NC

Iron Deficiency Anemia - Raleigh NC

Birth Control - Raleigh NC

Tinnitus - Raleigh NC

Stomach Ulcer Prevention - Raleigh NC

Ulcerative Colitis - Raleigh NC

Crohn's Disease - Raleigh NC

Ulcerative Proctitis / Proctosigmoiditis - Raleigh NC

Osteoarthritis of the Knee - Raleigh NC

Flu Treatment - Raleigh NC

Sleep Disorder Study for 3rd Shift Workers - Raleigh NC

Chronic Constipation - Raleigh NC

Decreased Sexual Desire in Postmenopausal Women - Raleigh NC

Diabetic Gastroparesis - Raleigh NC

Within 50 Miles

Within 100 Miles

Diabetic Gastroparesis - Fayetteville NC

Restless Legs Syndrome (RLS) - Winston-Salem NC

Restless Legs Syndrome - Winston-Salem NC

Diabetic Gastroparesis - Winston-Salem NC

High Blood Pressure (Hypertension) - Winston Salem NC

Restless Legs Syndrome - Salisbury NC


Clinical Trials Search

ClinicalConnection.com is a resource that provides individuals with information regarding clinical trials that are being conducted nationwide.
ClinicalConnection.com does not conduct these clinical trials nor endorse them. Please consult your doctor or physician before participating.