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Investigate the Effect of Different Doses of AZD3355 as add-on to Proton Pump Inhibitor (PPI) in Gastroesophageal Reflux Disease (GERD) Patients With Partial Response to PPI - NCT01005251-(Clinical Trial 386032)



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City:  Oklahoma City
State:  
OK
Zip Code:
Conditions: Gastroesophageal Reflux Disease - Acid Reflux - Heartburn - Regurgitation
Purpose: This study is being carried out to see whether AZD3355 is an effective treatment as an add-on to PPI therapy in patients with GERD with a partial response to PPI and to compare this with PPI treatment alone. Another goal of the study is to examine which of the investigated doses of AZD3355 is optimal for treatment of these patients. This study will also measure levels of drug in the blood and see how well it is tolerated.
Study summary:
Criteria: Inclusion Criteria: - Provision of informed consent prior to any study specific procedures - Have at least 6 months history of GERD - Continuously treated during the last 4 weeks before enrolment with daily optimized unchanged PPI therapy for any GERD indication Exclusion Criteria: - Patients that have not experienced any GERD symptom improvement at all during PPI treatment - Prior surgery of the upper gastrointestinal tract. - Subject who have any of the following conditions or diseases: Heart disease, Angina, Seizure disorders such as epilepsy, Congestive Heart Failure (CHF), Liver disease such as Cirrhosis or Hepatitis, Kidney disease, Lung disease or lung cancer, Cancer
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Data Source: ClinicalTrials.gov
Date Processed: August 16, 2010
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