View Clinical Trial (Medical Research Study)

Prochymal® (Human Adult Stem Cells) Intravenous Infusion Following Acute Myocardial Infarction (AMI) - NCT00877903-77030(Clinical Trial 395703)



ClinicalConnection.com has recently undergone an update and this page may no longer be up-to-date. Please Search For Clinical Trials to view the most current clinical trials listings.


Signup
City:  Houston
State:  
TX
Zip Code: 77030
Conditions: Myocardial Infarction
Purpose: The objective of the present study is to establish the safety and efficacy of Prochymal® following first acute myocardial infarction.
Study summary: The standard of care treatment for acute myocardial infarction (AMI) usually includes immediate perfusion, optimal pain relief, oxygen, aspirin or other anti-coagulants, Beta-Blockers, nitrates and Ace-inhibitors. However, because salvaging the viable myocardium is dependent on early reperfusion, only a minority of patients will reach the hospital within the time-window for myocardial rescue. Thus, even if the patient manages their tobacco use, hypertension, lipid levels, diabetes, weight and exercise, many patients will go on to develop Congestive Heart Failure (CHF). Though the medical management for CHF may improve symptoms and slow disease progression, such treatment cannot restore a functioning myocardium. A therapy that could improve the myocardial remodeling process and reduce the incidence or severity of CHF following acute MI would provide a significant benefit. The characteristics and biologic activity of Prochymal®, along with a good safety profile in human trials to date, suggest that Prochymal® may be a good candidate for addressing this unmet medical need.
Criteria: Inclusion Criteria: - Male or female between 21 and 85 years old - First heart attack within 7 days - Baseline LVEF 20-45% Exclusion Criteria: - Previous heart attack - Pacemaker or other device - Pregnant, breast-feeding, or intends to become pregnant during the study - Allergy to cow or pig derived products - Evidence of active malignancy or prior history of active malignancy - Major surgical procedure or major trauma within the past 14 days - Autoimmune disease (e.g., Lupus, Multiple Sclerosis) - Any medical condition, which in the opinion of the Investigator, renders participation unsuitable
If you are interested in this clinical trial please use the contact information above. If you would like to get additional information about this clinical trial please visit ClinicalTrials.gov.
Trials Alerts: If you would like to be notified of new clinical trials as they become available please register for a free account.
Data Source: ClinicalTrials.gov
Date Processed: February 17, 2011
Modifications to
this listing:		 Only selected fields are shown, please use the link above to view all information about this clinical trial.