Effect of Veramyst and Olopadatine 0.2% Opthalmic Solution on Allergy Symptoms - NCT01007253-60637 (Clinical Trial 399205)
Permalink: http://www.ClinicalConnection.com/exp/ExpandedPatientViewStudy399205.aspx
|
** Please review additional "Nearby Studies" on right ----->
|
|
 |
 |
|
| City: |
|
Chicago |
|
State:
|
|
IL |
| Zip Code: |
|
60637 |
| Conditions: |
|
Seasonal Allergic Rhinitis |
| Purpose: |
|
People who have hayfever or allergic rhinitis often complain about eye symptoms associated
with their nasal symptoms. How people with hayfever develop eye symptoms is not clear. The
purpose of this study is to better understand the generation of eye symptoms in patients
with allergic rhinitis. We have previously shown that placing the substance that subjects
are allergic too in their nose causes both nose and eye symptoms. This can be explain by a
parasympathetic neurogenic reflex from the nose to the eye. Such a reflex would readily
explain the tearing and watery eye symptoms, but does not explain the itch. In this study,
we are going to address one possible explanation for the itch; does an axonal neurogenic
reflex stimulate mast cells in the eye to release histamine, which then causes the itch? We
will do this by placing an antihistamine drop in the eye and challenge the nose with
allergen. We will also attempt to demonstrate that mast activation isn't effected by
blocking the initiating of the reflex with a nasal steroid, as done in our previous study,
and showing that the addition of an antihistamine does not add to the reduction of symptoms.
|
| Study summary: |
|
|
| Criteria: |
|
Inclusion Criteria
1. Males and females between 18 and 45 years of age.
2. History of grass and/or ragweed allergic rhinitis.
3. Positive skin test to grass and/or ragweed antigen.
4. Positive response to screening nasal challenge.
Exclusion Criteria
1. Physical signs or symptoms suggestive of renal, hepatic or cardiovascular disease.
2. Pregnant or lactating women.
3. Upper respiratory infection within 14 days of study start.
4. FEV1<80% of predicted at screening for subjects with history of mild asthma. |
|
|
|
| Study is available at: |
|
The University of Chicago
Chicago, IL 60637
United States
Primary Contact:
Marcy deTineo, BSN, CCRC
Email: mdetineo@surgery.bsd.uchicago.edu
Phone: 773-702-5889 |
|
|
If you are interested in this clinical trial please use the contact information above. If you would like to get additional information about this clinical trial please visit ClinicalTrials.gov.
|
| Trials Alerts: |
|
If you would like to be
notified of new clinical trials as they become available please
register for a free account.
|
|
| Data Source: |
|
ClinicalTrials.gov |
| Date Processed: |
|
March 16, 2010 |
Modifications to
this listing: |
|
Only selected fields are shown, please use the link
above to view all information about this clinical trial. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| |
|
|
| |
|
|
| |
|
|
| |
|
|
| |
|
|
| |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Clinical trials are medical research studies designed to test the safety and/or
effectiveness of new drugs, devices, or treatments in humans. These studies are
conducted worldwide for a range of conditions and illnesses. Learn more about
clinical research and participating in a study at
About Clinical Trials.
|
|
|
|
|