| City: |
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Bethesda |
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State:
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MD |
| Zip Code: |
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20892 |
| Conditions: |
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Childhood Obsessive-Compulsive Disorder - Autism Spectrum Disorders |
| Purpose: |
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Background:
- Obsessive-compulsive disorder (OCD) is a common childhood disorder that often does not
respond to standard treatments. Researchers are exploring the role that a brain
chemical called glutamate plays in symptoms of OCD, and are testing a drug called
riluzole that reduces glutamate to see if changing the levels of glutamate in the brain
will help treat the disorder.
- Researchers are interested in using magnetic resonance spectroscopy (MRS), a type of
magnetic imaging, to take pictures of various chemicals in the brain. MRS images will
be used to detect changes in brain levels of glutamate in children taking riluzole.
Objectives:
- To use magnetic resonance spectroscopy to study the levels of glutamate in the brains of
children and adolescents who have been taking riluzole.
Eligibility:
- Children and adolescents ages 7 to 17 who are enrolled in the current NIMH riluzole trial
protocol (05-M-0225), who are able to lie still in the scanner for about an hour each time,
and who are willing to have up to three MRS scans.
Design:
- Researchers will study some children/adolescents before they begin to take the study
medication riluzole or placebo-these children will have an MRS scan before starting the
study medication. The scan will take about an hour.
- About 2 weeks after reaching the full dose on the study medication, participants will
have a second hour-long MRS scan. Participants will have a third MRS scan after being
on the study medication for 12 weeks.
- Some children who have already completed 12 weeks on riluzole or placebo, and are now
taking riluzole, will have only one MRS scan.
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| Study summary: |
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Objective
This study uses magnetic resonance spectroscopy (MRS) to measure the neurotransmitter
glutamate in the anterior cingulate cortex (and, if tolerated, the left caudate nucleus and
possibly the thalamus) in children and adolescents.
Study Population
All of the subjects will be participants in an ongoing double-blind placebo-controlled trial
(05-M-0225) of a glutamate antagonist, the drug riluzole, for Obsessive-Compulsive Disorder
(OCD). The subjects are male and female children and adolescents, ages 7-17 years. They will
all have met criteria for clinically significant OCD and will have failed to benefit from
standard-of-care treatments or have been unable to tolerate the treatments. Some of the
subjects will also have a diagnosis on the autism spectrum.
Design
In one group of sixteen young people, glutamate will be measured in the anterior cingulate
cortex at three points in time:
- at baseline, before starting riluzole or placebo;
- within ten to fourteen days of the baseline evaluation, after reaching full dose of the
study drug (active drug or placebo) to which the sixteen subjects have just been
randomized;
- at the end of the twelve weeks of the double-blind phase of the study.
In a second group of sixteen young people, all of whom are subjects in the open-label phase
of the same study, glutamate will be measured (first) in the anterior cingulate cortex at a
single point in time when each subject has achieved steady state on the open-label drug
riluzole. If the subject tolerates additional time in the scanner, glutamate will also be
measured in the left caudate and possibly in the left thalamus. Glutamate levels in this
group will be correlated with change in OCD measures.
Outcome Measures
- In the first group, change in glutamate activity in anterior cingulate associated with
active drug (riluzole) administration, as compared with change in glutamate activity
for the subjects taking placebo.
- In the second group, correlation between serum riluzole level, glutamate activity (or
flux) in anterior cingulate (and possibly in the caudate and thalamus), and therapeutic
effect. |
| Criteria: |
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- INCLUSION CRITERIA:
Subjects may be included in the study only if they meet all of the following criteria:
1. Male or female subjects, 7 to 17 years of age.
2. Female subjects of childbearing potential must be using a medically accepted means of
contraception or must remain abstinent.
3. Each legal guardian must have a level of understanding sufficient to agree to all
required tests and examinations. Each legal guardian must understand the nature of
the study. Each legal guardian must consent to study protocol.
4. Subjects must fulfill DSM-IV criteria for (OCD) and have a CY-BOCS score of greater
than 20. In the double-blind phase, subjects enrolled in the combined OCD and ASD
cohort must also meet DSM-IV criteria for Pervasive Developmental Disorder as well as
OCD.
5. Each subject already taking medicine must be taking usually effective doses of a
medicine demonstrated to be effective in childhood OCD, must have been stable on that
dose for at least six weeks, and must have no newly recognized or intolerable adverse
effects from that medicine. Subjects who are currently not taking such a medication
must have had adequate trial in the past of at least one medicine that has been shown
to be effective for the symptoms of childhood OCD, and must have failed to see
improvement or must have had intolerable adverse effects from the medicine.
6. Subjects must be able to swallow capsules.
7. Subject in this protocol will all be enrolled in the riluzole for childhood OCD
protocol (NIH 05-M-0225).
EXCLUSION CRITERIA:
Subjects will be excluded from the study for any of the following reasons:
1. Presence of psychotic symptoms or lifetime history of schizophrenia, bipolar
disorder, other psychotic disorder, or other serious unstable psychiatric illness.
Medicially unstable due to binging, purging, or starvation.
2. Judged clinically to be at risk for suicide (suicidal ideation, severe depression, or
other factors). Diagnosis of DSM-IV Major Depressive Disorder is not necessarily an
exclusion criterion.
3. Disabling Tic Disorder requiring contraindicated medicines.
4. Female subjects who are pregnant, nursing, or unwilling to use effective
contraception.
5. Serious unstable illnesses, including gastroenterologic, respiratory, cardiovascular
(including ischemic heart disease), endocrinologic, neurologic, immunologic, or
hematologic disease.
6. Renal or hepatic dysfunction that would interfere with excretion or metabolism of
riluzole as evidenced by increase above upper limits of normal for BUN/creatinine, or
more than two-fold elevation above upper limits of normal of serum transaminases
(ALT/SGPT, AST/SGOT), gamma glutamate (GGT), or bilirubin.
7. Documented history of hypersensitivity or intolerance to riluzole.
8. DSM-IV Substance Abuse Disorder within the past 90 days or Substance Dependence
Disorder within the past 5 years, or any use of tobacco.
9. Taking contraindicated drugs.
10. Unable to swallow capsules.
11. In addition, patients will not receive cognitive-behavior therapy during the period
of the study. |
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| Study is available at: |
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National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, MD 20892
United States
Primary Contact:
Patient Recruitment and Public Liaison Office
Email: prpl@mail.cc.nih.gov
Phone: (800) 411-1222 |
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If you are interested in this clinical trial please use the contact information above. If you would like to get additional information about this clinical trial please visit ClinicalTrials.gov.
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| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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March 23, 2011 |
Modifications to
this listing: |
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Only selected fields are shown, please use the link
above to view all information about this clinical trial. |
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