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View Clinical Trial (Medical Research Study)
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Evaluation of the Genetics of Bipolar Disorder - NCT00001174-20892 (Clinical Trial 448253)
Permalink: http://www.ClinicalConnection.com/exp/ExpandedPatientViewStudy448253.aspx
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| City: |
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Bethesda |
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State:
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MD |
| Zip Code: |
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20892 |
| Conditions: |
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Mania - Bipolar, Disorder - Depression - Mood Disorder - Schizoaffective - Manic Depression |
| Purpose: |
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This study looks to identify genes that may affect a person's chances of developing bipolar
disorder (BP) and related conditions.
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| Study summary: |
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Bipolar affective disorder is a severe, heritable condition affecting about one percent of
the population. The mode of inheritance is poorly understood and probably involves multiple
loci of small to moderate effect. Genetic linkage has been reported to a number of
chromosomal regions; some findings have been replicated. In 1988 the NIMH began a national
archival database to search for susceptibility loci/genes in this condition. Its purpose was
to collect a large sample of interviews and cell lines from families suitable for linkage
and association studies. Since 1988, the NIMH-IRP has been an active site in this
multi-center study. The protocol was originally supervised by Elliot Gershon, MD (1988-July
1998) and Dennis L. Murphy, MD (July 1998 - January 2004). In January 2004, Francis J.
McMahon, M.D, took over supervision of the protocol. An expanded Consortium of sites
concentrating on families identified through a sib pair was approved in August 1998 by the
NIMH Extramural Program (MH 59535) via a competitive application. This Consortium added 450
new families and 2500 cell lines. Cell lines, clinical data, and 2 genome-wide sets of
microsatellite genotypes have been made freely available to the scientific community under
the auspices of the NIMH Center for Genetic Studies. In 2003, the IRB approved an amendment
to expand the ascertainment criteria to include sib-pairs with a diagnosis of bipolar II
disorder. Families ascertained in this manner are contributed to a second, large sample
being collected in collaboration with The Johns Hopkins University and the University of
Chicago, known as the CHIP study. In October 2003, the NIMH Extramural Program approved, via
a competitive application, an additional 4 years of support for the Consortium collection,
now including 11 extramural sites in addition to the IRP site. In this round, the focus
shifted from affected sibling pairs to parent-affected offspring triads, with the goal of
accruing a large sample suitable for future association studies. Both the Consortium and
CHIP projects have similar study design and essentially identical recruitment, evaluation,
and analysis procedures, so both projects are described together in what follows. |
| Criteria: |
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- INCLUSION CRITERIA:
Age > 18 yr
Able to provide informed consent
Diagnosed with bipolar disorder not attributable to substance abuse, neurological disease;
or 1st or 2nd degree realtive of an enrolled participant
Able to safely provide a blood or saliva sample
EXCLUSION CRITERIA:
Active alcohol or substance abuse |
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| Study is available at: |
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National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, MD 20892
United States
Primary Contact:
Diane M. Kazuba
Email: kazubad@intra.nimh.nih.gov
Phone: (301) 496-8977 |
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If you are interested in this clinical trial please use the contact information above. If you would like to get additional information about this clinical trial please visit ClinicalTrials.gov.
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| Data Source: |
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ClinicalTrials.gov |
| Date Processed: |
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March 15, 2010 |
Modifications to
this listing: |
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Only selected fields are shown, please use the link
above to view all information about this clinical trial. |
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Clinical trials are medical research studies designed to test the safety and/or
effectiveness of new drugs, devices, or treatments in humans. These studies are
conducted worldwide for a range of conditions and illnesses. Learn more about
clinical research and participating in a study at
About Clinical Trials.
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