View Clinical Trial (Medical Research Study)

A Research Study To Assess The Effectiveness And Safety Of Different Doses Of Oral PF-00489791 In The Treatment Of Adult Patients With Pulmonary Arterial Hypertension - NCT00853112-95817(Clinical Trial 458112)



ClinicalConnection.com has recently undergone an update and this page may no longer be up-to-date. Please Search For Clinical Trials to view the most current clinical trials listings.


Signup
City:  Sacramento
State:  
CA
Zip Code: 95817
Conditions: Hypertension, Pulmonary
Purpose: Study will assess PF-00489791 efficacy and safety in Pulmonary Arterial Hypertension (PAH)
Study summary:
Criteria: Inclusion Criteria: - Idiopathic or familial pulmonary arterial hypertension (PAH) - Mean PAP at least 25 mm Hg, PCWP < 15 mm Hg at rest - For females of child-bearing potential negative pregnancy test at screening and use of contraception during the study and 4 weeks after its completion - Signed and dated informed consent - Willingness to comply with the study plan and procedures Exclusion Criteria: - pulmonary arterial hypertension (PAH)other than idiopathic or familial - For females, pregnancy or lactation - Use of specific PAH treatments, potent CYP3A4 inhibitors, protease inhibitors, alpha blockers or arginine 30 days prior tio randomization and during the study - Change of dose or class of standard background PAH therapy, i.e. oxygen, calcium channel blockers, digoxin, diuretics 30 days prior tio randomization and during the study - Large shift in altitude (defined as >5000 feet or 1524 meters) during 90 days prior to baseline visit and/or during the study visit - Subjects with intracardiac shunts and/or serious heart, lung or other health conditions - HIV positive subjects - Subjects participating in another clinical trial with an investigational drug or device - Subjects with degenerative retinal disorders, history of non-arteritic anterior ischemic optic neuropathy or untreated proliferative diabetic retinopathy - Allergies and previous intolerance of PDE5 inhibitors - Alcohol or drug abuse - Blood donation during the study, or 1 month before or after the study
If you are interested in this clinical trial please use the contact information above. If you would like to get additional information about this clinical trial please visit ClinicalTrials.gov.
Trials Alerts: If you would like to be notified of new clinical trials as they become available please register for a free account.
Data Source: ClinicalTrials.gov
Date Processed: August 3, 2010
Modifications to
this listing:		 Only selected fields are shown, please use the link above to view all information about this clinical trial.