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Exercise Interventions During Voluntary Weight Loss in Obese Older Adults - NCT01065636-87108(Clinical Trial 494219)



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City:  Albuquerque
State:  
NM
Zip Code: 87108
Conditions: Obesity
Purpose: Obesity causes frailty in obese older adults by exacerbating the age-related decline in physical function. However, appropriate management of obesity in older adults is controversial. Weight loss without exercise could worsen frailty by accelerating the usual age-related decline in muscle and bone mass that leads to sarcopenia and osteopenia, respectively. Because of the important problem of frailty in obese older adults, it is important to determine the most efficacious approach in reducing, or even reversing frailty in this population. The primary objective of this proposal is to evaluate which distinct type of physical exercise (resistance, aerobic, or combined resistance + aerobic) is most efficacious in preventing the weight-loss-induced reduction in muscle and bone mass and reversing frailty in obese older adults.
Study summary:
Criteria: Inclusion Criteria: - 65-85 years old - Obese men and women (BMI > 30 kg/m2) - Stable weight (±2 kg) during the last 6 mos. - Must be sedentary (regular exercise <1 h/wk or <2 x/wk for the last 6 mos. - Be judged, during the initial screening, to be well motivated and reliable Exclusion Criteria: - Any major chronic diseases - Any condition that would interfere with exercise or dietary restriction, in which exercise or dietary restriction are contraindicated, or that would interfere with interpretation of results. - Cardiopulmonary disease (e.g., recent MI, unstable angina, stroke etc.) - Unstable disease (e.g., CHF) that would contraindicate exercise or dietary restriction - Severe orthopedic/musculoskeletal or neuromuscular impairments that would contraindicate participation in exercise - Visual or hearing impairments that interfere with following directions - Diagnosis of dementia - History of malignancy during the past 5 yr - Recent use of bone acting drugs (e.g. use of estrogen, or androgen containing compound, raloxifene, calcitonin, parathyroid hormone during the past year or biphosphonates during the last two years) - Individuals on insulin or with a fasting blood glucose of > 140mg/dl, and/or a 2 hour blood glucose of >250 mg/dl - No commitments, life situations or conditions that would interfere with their participation in the study
Study is available at: New Mexico VA Medical Center
Albuquerque, NM 87108
United States

Primary Contact:
Cheryl Reich, RN, MSN,AOCN
Email: cheryl.reich@va.gov
Phone: 505-265-2711
If you are interested in this clinical trial please use the contact information above. If you would like to get additional information about this clinical trial please visit ClinicalTrials.gov.
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Data Source: ClinicalTrials.gov
Date Processed: March 23, 2011
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