A Phase IIb Study to Investigate the Efficacy and Tolerability of Cinaciguat (150 µg/h, 100 µg/h, 50 µg/h) Given Intravenously to Subjects With Acute Decompensated Chronic Congestive Heart Failure (ADHF) - NCT01064037-45267(Clinical Trial 685441)
ClinicalConnection.com has recently undergone an update and this page may no longer be up-to-date. Please Search For Clinical Trials to view the most current clinical trials listings.
| City: |
|
Cincinnati |
|
State:
|
|
OH |
| Zip Code: |
|
45267 |
| Conditions: |
|
Heart Failure - Heart Decompensation |
| Purpose: |
|
A placebo controlled, double-blind and randomized study to assess different doses of a new
drug (BAY58-2667) given intravenously, to evaluate if it is safe and can help to improve the
well-being of patients with acute decompensated heart failure.
|
| Study summary: |
|
|
| Criteria: |
|
Inclusion Criteria:
- Male and non-pregnant, non-lactating female subjects, age >/= 18 years of age; or
women without childbearing potential defined as postmenopausal women aged 55 years or
older, women with bilateral tubal ligation, women with bilateral ovarectomy, and
women with a hysterectomy
- Subjects must have the clinical diagnosis of congestive heart failure (CHF) made at
least three months prior to enrollment
- Subjects must experience worsening of both of the symptoms below leading to
hospitalization at the time of entry into the study: dyspnea and clinical evidence of
volume overload
Exclusion Criteria:
- Acute de-novo heart failure
- Acute myocardial infarction and/or myocardial infarction within 30 days
- Valvular heart disease requiring surgical intervention during the course of the study
- Heart failure due to or associated with uncorrected primary valvular disease,
malfunctioning artificial heart valve, or uncorrected congenital heart disease
- Primary hypertrophic cardiomyopathy
- Acute inflammatory heart disease, eg, acute myocarditis
- Unstable angina requiring angiography |
|
|
|
|
|
|
|
|
If you are interested in this clinical trial please use the contact information above. If you would like to get additional information about this clinical trial please visit ClinicalTrials.gov.
|
| Trials Alerts: |
|
If you would like to be
notified of new clinical trials as they become available please
register for a free account.
|
|
| Data Source: |
|
ClinicalTrials.gov |
| Date Processed: |
|
February 18, 2011 |
Modifications to
this listing: |
|
Only selected fields are shown, please use the link
above to view all information about this clinical trial. |
|
|
|
|
|
|
|
|