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D-cycloserine Adjunctive Treatment for Posttraumatic Stress Disorder (PTSD) in Adolescents - NCT01157429-70112(Clinical Trial 688180)



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City:  New Orleans
State:  
LA
Zip Code: 70112
Conditions: Posttraumatic Stress Disorder - PTSD
Purpose: The purpose of this study is to show whether D-cycloserine in combination with cognitive behavioral therapy (CBT) is more effective than CBT alone to reduce symptoms of posttraumatic stress disorder (PTSD) in 13-18 year-old children.
Study summary: While most individuals with PTSD treated with cognitive behavioral therapy (CBT) show improvement, they still have some enduring symptoms and functional impairment. Accordingly, there is a need for treatment advances. D-cycloserine (DCS), an antibiotic that has been used for over 50 years, has also been found to have positive effects on cognition and anxiety. DCS was found to enhance learning and memory, and also facilitates extinction of fear reactions. However, DCS only produces an extinction effect when paired with behavioral training, not when simply given alone. Thus, the medication only needs to be given for seven doses in this research and youth do not need to take the medication long term. The research also includes a three-month follow-up.
Criteria: Inclusion Criteria: - Certain number of PTSD symptoms plus functional impairment - Must be able to swallow pills Exclusion Criteria: - Certain medications - Serious kidney or liver disease - Epilepsy - Bipolar disorder - Psychosis
Study is available at: Tulane University Health Sciences Center, 1440 Canal St.
New Orleans, LA 70112
United States

Primary Contact:
Jennifer Liriano, BA
Email: jliriano@tulane.edu
Phone: 504-988-2165

Secondary Contact:
Jennifer Liriano, BA
Email: jliriano@tulane.edu
Phone: 504-988-2165
If you are interested in this clinical trial please use the contact information above. If you would like to get additional information about this clinical trial please visit ClinicalTrials.gov.
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Data Source: ClinicalTrials.gov
Date Processed: March 23, 2011
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