Chicago, Illinois 60637

  • Related Disorders

Purpose:

The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. Comparisons between nitrous oxide, opiates, and benzodiazepine antagonists will be made. To examine reinforcing effects of brief exposures to nitrous oxide in healthy volunteers.


Criteria:

Please contact site for information.


Study is Available At:


Original ID:

NIDA-08391-8


NCT ID:

NCT00000256


Secondary ID:

R01DA008391


Study Acronym:


Brief Title:

Reinforcing Effects of Brief Exposures to Nitrous Oxide - 8


Official Title:

Reinforcing Effects of Brief Exposures to Nitrous Oxide


Overall Status:

Completed


Study Phase:

N/A


Genders:

Both


Minimum Age:

22 Years


Maximum Age:

34 Years


Quick Facts

Healthy Volunteers
Oversight Has DMC
Study Is FDA Regulated
Study Is Section 801
Has Expanded Access

Study Source:

University of Chicago


Oversight Authority:

United States: Federal Government


Reasons Why Stopped:


Study Type:

Interventional


Study Design:

Allocation: Non-Randomized, Intervention Model: Cr


Number of Arms:

4


Number of Groups:

0


Total Enrollment:

11


Enrollment Type:

Actual


Overall Contact Information

Official Name:James Zacny, Ph.D.
Principal Investigator
University of Chicago

Study Dates

Start Date:August 1995
Completion Date:November 1996
Completion Type:Actual
Primary Completion Date:November 1996
Primary Completion Type:Actual
Verification Date:May 2015
Last Changed Date:May 26, 2015
First Received Date:September 20, 1999

Study Outcomes

Outcome Type:Primary Outcome
Measure:Choice of nitrous oxide vs placebo
Time Frame:After 1.5 min of inhalation each of nitrous oxide then placebo
Safety Issues:False
Description:Subjects underwent 4 sessions consisting of 2 sample tests (inhaling placebo and inhaling varying doses of N2O), then choosing which inhalant they wanted for a choice test. The subject & the technician administering the inhalant were blinded. During

Study Interventions

Intervention Type:Drug
Name:80% N2O
Arm Name:Placebo + 80% N2O
Intervention Type:Drug
Name:60% N2O
Arm Name:Placebo + 60% N2O
Intervention Type:Drug
Name:40% N2O
Arm Name:Placebo + 40% N2O
Intervention Type:Drug
Name:20% N2O
Arm Name:Placebo + 20% N2O

Study Arms

Study Arm Type:Active Comparator
Arm Name:Placebo + 80% N2O
Description:0% N2O inhaled during psychomotor testing, 80% N2O inhaled during psycho motor testing, then subject's choice of the 2.
Study Arm Type:Active Comparator
Arm Name:Placebo + 60% N2O
Description:0% N2O inhaled during psychomotor testing, 60% N2O inhaled during psycho motor testing, then subject's choice of the 2.
Study Arm Type:Active Comparator
Arm Name:Placebo + 40% N2O
Description:0% N2O inhaled during psychomotor testing, 40% N2O inhaled during psycho motor testing, then subject's choice of the 2.
Study Arm Type:Active Comparator
Arm Name:Placebo + 20% N2O
Description:0% N2O inhaled during psychomotor testing, 20% N2O inhaled during psycho motor testing, then subject's choice of the 2.

Study Agencies

Agency Class:Other
Agency Type:Lead Sponsor
Agency Name:University of Chicago
Agency Class:NIH
Agency Type:Collaborator
Agency Name:National Institute on Drug Abuse (NIDA)

Sample and Retention Information

There are no available Sample and Retention Information

Study References

There are no available Study References

Data Source: ClinicalTrials.gov

Date Processed: July 27, 2021

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