Bethesda, Maryland 20892

  • Postpoliomyelitis Syndrome

Purpose:

This study will investigate problems with muscle weakness and control using electromyography-a test of nerve-muscle cell communication. Advanced techniques called single fiber electromyography and macro-electromyography, which evaluate individual muscle fibers, will be used. Besides aiding in diagnosis, these tests provide information about disease progression that may be useful in guiding therapy. Adult patients with suspected neurological disorders of muscle control and weakness may be eligible for this study. Normal volunteers may also participate. For the electromyography procedure, a special needle is inserted into a muscle. The patient will slightly tense the muscle and maintain the tension while electrical signals from the muscle fibers are being recorded. The electrical signals are played through a loudspeaker, providing feedback to help the patient tense the muscle the appropriate amount. The test, which is usually done for only one muscle, takes 1 to 2 hours. If needed, short breaks can be taken. If the patient cannot maintain tension in the muscle for the entire test period, a nerve will be stimulated to activate the muscle. A thin needle is inserted near the nerve, and a series of small electrical shocks are given to activate a nerve fiber. The electromyography needle is inserted into the muscle to measure the response, as described above. A neurologist receiving specialized training in clinical neurophysiology will do the electromyography procedure under the direct supervision of an experienced neurologist.


Study summary:

This is a training protocol to enable fellows in clinical neurophysiology to learn and perform technically advanced electrodiagnostic studies, such as single fiber EMG and macro EMG, on patients with neuromuscular diseases.


Criteria:

INCLUSION CRITERIA: Adult patients with weakness or motor dysfunction: 8/year. Normal volunteers, adults: 2/year. EXCLUSION CRITERIA: Anticoagulation or uncorrected bleeding disorder. Children are not optimal subjects for fellows undergoing training in these techniques and will be excluded.


Study is Available At:


Original ID:

000072


NCT ID:

NCT00004553


Secondary ID:

00-N-0072


Study Acronym:


Brief Title:

Electromyography to Diagnose Neuromuscular Disorders


Official Title:

Diagnosis of Neuromuscular Disorders With Specialized Electromyographic Studies


Overall Status:

Completed


Study Phase:

N/A


Genders:

Both


Minimum Age:

N/A


Maximum Age:

N/A


Quick Facts

Healthy Volunteers
Oversight Has DMC
Study Is FDA Regulated
Study Is Section 801
Has Expanded Access

Study Source:

National Institutes of Health Clinical Center (CC)


Oversight Authority:

United States: Federal Government


Reasons Why Stopped:


Study Type:

Interventional


Study Design:

N/A


Number of Arms:

0


Number of Groups:

0


Total Enrollment:

30


Enrollment Type:


Study Dates

Start Date:February 2000
Completion Date:November 2005
Verification Date:November 2005
Last Changed Date:March 3, 2008
First Received Date:February 4, 2000

Study Outcomes

There are no available Study Outcomes

Study Interventions

Intervention Type:Procedure
Name:Electromyography

Study Arms

There are no available Study Arms

Study Agencies

Agency Class:NIH
Agency Type:Lead Sponsor
Agency Name:National Institute of Neurological Disorders and Stroke (NINDS)

Sample and Retention Information

There are no available Sample and Retention Information

Study References

Reference Type:Reference
Citation:Grimby G, Stalberg E, Sandberg A, Stibrant Sunnerhagen K. An 8-year longitudinal study of muscle strength, muscle fiber size, and dynamic electromyogram in individuals with late polio. Muscle Nerve. 1998 Nov;21(11):1428-37.
PMID:9771666
Reference Type:Reference
Citation:Sanders DB, Stalberg EV. AAEM minimonograph #25: single-fiber electromyography. Muscle Nerve. 1996 Sep;19(9):1069-83. Review.
PMID:8761262

Data Source: ClinicalTrials.gov

Date Processed: July 27, 2021

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