Hartford, Connecticut 06102

  • Ovarian Cancer


RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development of cancer. It is not yet known whether fenretinide given before surgery is more effective in preventing ovarian cancer than surgery alone. PURPOSE: Randomized clinical trial to compare the effectiveness of fenretinide followed by surgery with that of surgery alone in preventing ovarian cancer in patients who are at increased risk.

Study summary:

OBJECTIVES: - Compare the frequency of histopathology markers or precursor lesions of the ovaries, including surface papillomatosis, invaginations, pseudostratification, and inclusion cysts, removed from patients at increased risk for ovarian cancer between those receiving fenretinide vs those undergoing immediate oophorectomy. - Determine the relative abundance of markers of cell proliferation and apoptosis in cancer-prone ovaries of patients treated with fenretinide. OUTLINE: This is a randomized, multicenter study. Patients are randomized to 1 of 2 arms. - Arm I: Patients undergo prophylactic oophorectomy. - Arm II: Patients receive oral fenretinide once daily for 27 days every 30 days for 6-8 weeks. Treatment continues in the absence of unacceptable toxicity or diagnosis of malignancy. After completion of fenretinide, patients undergo prophylactic oophorectomy. Patients are followed every 3 months for 2 years and then every 6 months for 3 years. PROJECTED ACCRUAL: A total of 71 patients will be accrued for this study within 2 years.


DISEASE CHARACTERISTICS: - Increased risk for ovarian cancer secondary to 1 of the following: - Evidence of a BRCA1 or BRCA2 genetic mutation - Family history of 1 or more first-degree relatives diagnosed with ovarian cancer prior to 50 years of age - Family history of 1 first-degree relative with ovarian cancer (any age) AND 1 or more first- or second-degree relatives diagnosed with breast or ovarian cancer - Personal history of breast cancer (at any age) AND 1 or more first- or second-degree relative diagnosed with breast or ovarian cancer at any age - Meets any 1 of the following criteria: - Ashkenazi Jewish ethnicity with 1 first-degree or 2 second-degree relatives with breast* and/or ovarian cancer - Ashkenazi Jewish ethnicity with diagnosed breast* cancer in patient - Greater than 20% probability of carrying BRCA1/2 mutation with a family history of breast and ovarian cancer NOTE: * Where breast cancer is required to meet this criteria, diagnosis must occur prior to menopause or at ≤ 50 years old if age at menopause is unknown - Planned prophylactic oophorectomy - Normal pelvic exam within the past 6 weeks PATIENT CHARACTERISTICS: Age: - 18 and over Performance status: - GOG 0-1 Life expectancy: - At least 12 months Hematopoietic: - WBC at least 4,000/mm^3 - Platelet count at least 100,000/mm^3 Hepatic: - Bilirubin no greater than 1.5 mg/dL - SGOT no greater than 2 times upper limit of normal (ULN) Renal: - Creatinine no greater than 1.5 mg/dL OR - Creatinine clearance at least 60 mL/min - Triglyceride less than 2 times ULN (fasting) Cardiovascular: - No myocardial infarction within the past 3 months - No active angina - No unstable heart rhythms - No clinically evident congestive heart failure Other: - No uncontrolled medical illness that would preclude study participation - No uncontrolled diabetes - No uncontrolled psychiatric illness - Not pregnant or nursing - Negative pregnancy test - Fertile patients must use effective barrier contraception PRIOR CONCURRENT THERAPY: Biologic therapy: - Not specified Chemotherapy: - At least 3 months since prior chemotherapy Endocrine therapy: - At least 3 months since prior hormonal therapy - At least 8 weeks since prior hormone replacement therapy - At least 8 weeks since prior oral, injectable, or implantable contraceptives - No concurrent hormonal therapy, including hormone replacement therapy Radiotherapy: - At least 3 months since prior radiotherapy - No prior radiotherapy to pelvis for malignancy Surgery: - See Disease Characteristics Other: - At least 3 months since prior investigational treatment - No concurrent nutritional supplements except a daily multivitamin with less than 25,000 IU of vitamin A - No prior non-steroidal anti-inflammatory drugs (NSAIDs) on a regular (chronic or daily) basis within the past 6 months - No concurrent NSAIDs on a regular (chronic or daily) basis - Concurrent aspirin at a dose of 81 mg/day allowed

Study is Available At:

Original ID:




Secondary ID:


Study Acronym:

Brief Title:

Fenretinide Followed by Surgery Compared With Surgery Alone in Preventing Ovarian Cancer in Patients at Increased Risk

Official Title:

An Exploratory Evaluation of Fenretinide (4-HPR) as a Chemopreventive Agent for Ovarian Carcinoma

Overall Status:


Study Phase:




Minimum Age:

18 Years

Maximum Age:


Quick Facts

Healthy Volunteers
Oversight Has DMC
Study Is FDA Regulated
Study Is Section 801
Has Expanded Access

Study Source:

Gynecologic Oncology Group

Oversight Authority:

United States: Food and Drug Administration

Reasons Why Stopped:

Withdrawn due to poor accrual

Study Type:


Study Design:

Allocation: Randomized, Primary Purpose: Prevent

Number of Arms:


Number of Groups:


Total Enrollment:


Enrollment Type:


Overall Contact Information

Official Name:Mary B. Daly, MD, PhD
Study Chair
Fox Chase Cancer Center

Study Dates

Start Date:September 2002
Primary Completion Date:December 2006
Primary Completion Type:Actual
Verification Date:November 2006
Last Changed Date:June 7, 2013
First Received Date:June 6, 2001

Study Outcomes

There are no available Study Outcomes

Study Interventions

Intervention Type:Drug
Intervention Type:Procedure
Name:conventional surgery

Study Arms

There are no available Study Arms

Study Agencies

Agency Class:Other
Agency Type:Lead Sponsor
Agency Name:Gynecologic Oncology Group
Agency Class:NIH
Agency Type:Collaborator
Agency Name:National Cancer Institute (NCI)

Sample and Retention Information

There are no available Sample and Retention Information

Study References

There are no available Study References

Data Source: ClinicalTrials.gov

Date Processed: April 03, 2020

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