Expired Study
This study is not currently recruiting Study Participants on ClinicalConnection.com. If you would like to find active studies please search for clinical trials.

Omaha, Nebraska 68105


The purpose of this study is to test the use of time-released bupropion (Wellbutrin) in patients receiving treatment for alcohol abuse/dependence as an aid to stop smoking. Patients will receive either a time-released bupropion or placebo. Both groups will receive nicotine replacement therapy during the 9 week study. A final followup assessment will be conducted 6 months from the start of treatment.


Inclusion Criteria: - Currently a patient in the Omaha VA Medical Center, Substance Abuse Treatment Center (SATC) or at Catholic Charities Campus for Hope. - Have a diagnosis of alcohol abuse or alcohol dependence. - Smoke 20 or more cigarettes/day (may also smoke pipes/cigars). - Be interested in quitting smoking. - Provide name, addresses, and phone numbers of at least two individuals who can provide information on their alcohol, nicotine, and other drug use during the follow-up period. - If female, patient must a) be of non-childbearing potential, b) have a negative pregnancy test, c) sign a document stating they do not plan on becoming pregnant during the study. - Agree to sign informed consent. - Able to read and understand study-related forms and procedures. Exclusion Criteria: - Advanced cardiac, pulmonary, renal, or liver disease. - History of seizures. - History of brain tumor or significant head trauma. - History of bulimia or anorexia nervosa. - Current major depressive disorder or past history of panic disorders, schizophrenia, or bipolar affective disorder. - Using psychoactive drugs. - Receiving treatment with medications that lower seizure thresholds. - Use of an investigational drug in any study in the past four weeks. - Currently using any asthma medication. - Used time-released bupropion in the past 12 months. - Currently using any other treatments to stop smoking.

Study is Available At:

Original ID:




Secondary ID:

Study Acronym:

Brief Title:

Bupropion as a Smoking Cessation Aid in Alcoholics

Official Title:

Bupropion as a Smoking Cessation Aid in Alcoholics

Overall Status:


Study Phase:

Phase 4



Minimum Age:

25 Years

Maximum Age:

75 Years

Quick Facts

Healthy Volunteers
Oversight Has DMC
Study Is FDA Regulated
Study Is Section 801
Has Expanded Access

Study Source:

National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Oversight Authority:

United States: Federal Government

Reasons Why Stopped:

Study Type:


Study Design:

Allocation: Randomized, Endpoint Classification:

Number of Arms:


Number of Groups:


Total Enrollment:


Enrollment Type:

Study Dates

Start Date:May 2002
Completion Date:April 2005
Completion Type:Actual
Primary Completion Date:April 2005
Primary Completion Type:Actual
Verification Date:January 2008
Last Changed Date:January 25, 2008
First Received Date:August 28, 2002

Study Outcomes

There are no available Study Outcomes

Study Interventions

Intervention Type:Drug
Name:bupropion (Wellbutrin)

Study Arms

There are no available Study Arms

Study Agencies

Agency Class:NIH
Agency Type:Lead Sponsor
Agency Name:National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Sample and Retention Information

There are no available Sample and Retention Information

Study References

There are no available Study References

Data Source: ClinicalTrials.gov

Date Processed: January 21, 2020

Modifications to this listing: Only selected fields are shown, please use the link below to view all information about this clinical trial.

This study is not currently recruiting Study Participants. The form below is not enabled.