Expired Study
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Little Rock, Arkansas 72205


Purpose:

The purpose of this trial is to determine the effect of a new drug, SGS742, on memory and cognition in patients with mild to moderate Alzheimer's disease.


Study summary:

SGS742 is a GABA(B) receptor antagonist. It is an orally active drug and possesses neurochemical and psychopharmacologic features that suggest it could improve memory and cognition in humans. The primary objective of the SGS742 clinical trial will be to determine the effect of SGS742 on memory and cognition in individuals diagnosed with mild to moderate Alzheimer's disease. The duration of the study is 3 months with 5 clinic visits.


Criteria:

Inclusion Criteria: - 55 to 90 years of age - Diagnosed with mild to moderate Alzheimer's disease - Willing caregiver - In general good health Exclusion Criteria: - Call 1-877-MY-MEMORY and ask to be referred to a study center located near you for entry criteria information. Prohibited Meds: - Alzheimer's medications (Aricept, Exelon, Remydl, Nemenda)


Study is Available At:


Original ID:

IA0061


NCT ID:

NCT00093951


Secondary ID:


Study Acronym:


Brief Title:

SGS742 in Patients With Mild to Moderate Alzheimer's Disease (AD)


Official Title:

A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase II Study of the Efficacy and Safety of SGS742 in Subjects With Mild to Moderate Alzheimer's Disease


Overall Status:

Completed


Study Phase:

Phase 2


Genders:

Both


Minimum Age:

55 Years


Maximum Age:

90 Years


Quick Facts

Healthy Volunteers
Oversight Has DMC
Study Is FDA Regulated
Study Is Section 801
Has Expanded Access

Study Source:

National Institute on Aging (NIA)


Oversight Authority:

United States: Food and Drug Administration


Reasons Why Stopped:


Study Type:

Interventional


Study Design:

Allocation: Randomized, Endpoint Classification:


Number of Arms:

0


Number of Groups:

0


Total Enrollment:

280


Enrollment Type:


Study Dates

Start Date:April 2004
Completion Date:September 2007
Completion Type:Actual
Primary Completion Date:September 2007
Primary Completion Type:Actual
Verification Date:February 2009
Last Changed Date:December 10, 2009
First Received Date:October 7, 2004

Study Outcomes

There are no available Study Outcomes

Study Interventions

Intervention Type:Drug
Name:SGS742

Study Arms

There are no available Study Arms

Study Agencies

Agency Class:Industry
Agency Type:Lead Sponsor
Agency Name:Saegis Pharmaceuticals

Sample and Retention Information

There are no available Sample and Retention Information

Study References

Reference Type:Reference
Citation:Froestl W, Gallagher M, Jenkins H, Madrid A, Melcher T, Teichman S, Mondadori CG, Pearlman R. SGS742: the first GABA(B) receptor antagonist in clinical trials. Biochem Pharmacol. 2004 Oct 15;68(8):1479-87.
PMID:15451390

Data Source: ClinicalTrials.gov

Date Processed: January 21, 2020

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