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Tacoma, Washington 98403

  • Psoriasis

Purpose:

- The primary objective of this study is to compare disease activity, as measured by PASI score, of two MEDI-507 dose levels (0.012 and 0.04 mg/kg) versus placebo administered by intravenous infusion every 2 weeks for a total of 8 infusions.


Criteria:

Inclusion Criteria: - Plaque psoriasis involving at least 10% of body surface area (Appendix B) - Age 18 through 65 years at the time of the first dose of study drug - Both males and females are eligible. However, sexually active females, unless surgically sterile or at least 1 year post-menopausal, must have used an effective method of avoiding pregnancy (including oral or implanted contraceptives, IUD, female condom, diaphragm with spermicide, cervical cap, abstinence, use of a condom by the sexual partner or sterile sexual partner) for 30 days prior to the first dose of study drug and must agree to continue using such precautions for 60 days after the final dose of study drug - Currently receiving no therapy for psoriasis except emollients (certain other over-the-counter products may be allowed with prior approval of the sponsor) - Written informed consent obtained from the patient - Ability to complete follow-up period of 188 days as required by the protocol Exclusion Criteria: - Pustular, guttate, or erythrodermic psoriasis as the predominant disease type - PASI score <8 - At screening (must be within 21 days before study entry) any of the following: lymphocyte count under 1,200 cells/mm3, WBC under 4,000 cells/mm3, hematocrit below 32%, platelets below 110,000 cells/mm3, creatinine, AST, ALT over 1.5 times upper limit of normal - At screening (must be within 21 days before study entry) any clinical evidence of HIV, hepatitis B, hepatitis C or active hepatitis A infection - Pregnancy (must have a negative serum pregnancy test within 21 days prior to the first dose of study drug, and urine pregnancy test must be negative on Study Day 0 before study entry) - History of cancer (except excision of basal cell carcinoma) - Any documented immunodeficiency - A history of prior administration of monoclonal antibodies or related proteins, with the exception of MEDI-507 (Note: prior recipients of MEDI-507 will require review and approval by the sponsor prior to entry) - Receipt of systemic retinoids, corticosteroids, cyclosporin A, methotrexate, phototherapy or coal tar treatment in the past 4 weeks - Use of topical therapy (except emollients) for psoriasis in the past 2 weeks (certain other over-the-counter products may be allowed with prior approval of the sponsor) - Receipt of any investigational drug therapy within 6 weeks before the first dose of study drug in this protocol (use of licensed agents for indications not listed in the package insert is permitted) - Current or planned participation in a research protocol in which an investigational agent or therapy may be administered - Nursing mother - Acute illness including infections - Clinical manifestations of significant end organ dysfunction or failure that may compromise the safety of the volunteer in the study - A known drug allergy or medical contraindication to ibuprofen


Study is Available At:


Original ID:

MI-CP074


NCT ID:

NCT00192452


Secondary ID:


Study Acronym:


Brief Title:

Study of MEDI-507 Administered by Intravenous Infusion to Adults With Plaque Psoriasis


Official Title:

A Phase II Randomized, Double-Blind, Placebo-Controlled Study of MEDI-507, a Humanized Monoclonal Antibody That Binds to the CD2 Receptor, Administered by Intravenous Infusion to Adults With Plaque Psoriasis


Overall Status:

Completed


Study Phase:

Phase 2


Genders:

Both


Minimum Age:

18 Years


Maximum Age:

64 Years


Quick Facts

Healthy Volunteers
Oversight Has DMC
Study Is FDA Regulated
Study Is Section 801
Has Expanded Access

Study Source:

MedImmune LLC


Oversight Authority:

United States: Food and Drug Administration


Reasons Why Stopped:


Study Type:

Interventional


Study Design:

Allocation: Randomized, Intervention Model: Sing


Number of Arms:

0


Number of Groups:

0


Total Enrollment:

120


Enrollment Type:


Overall Contact Information

Official Name:Stanley Pillemer, MD
Study Director
MedImmune LLC

Study Dates

Start Date:March 2001
Completion Date:December 2001
Verification Date:October 2006
Last Changed Date:October 23, 2006
First Received Date:September 13, 2005

Study Outcomes

Outcome Type:Secondary Outcome
Measure:Percentage of subjects with at least 75% improvement and those with at least 50% improvement will be compared.
Safety Issues:False
Outcome Type:Primary Outcome
Measure:Analyses of categorical data will be performed and analysis of continuous data will be performed using a one-way analysis of variance (ANOVA) with traetment group as a factor.
Safety Issues:False

Study Interventions

Intervention Type:Drug
Name:MEDI-507

Study Arms

There are no available Study Arms

Study Agencies

Agency Class:Industry
Agency Type:Lead Sponsor
Agency Name:MedImmune LLC

Sample and Retention Information

There are no available Sample and Retention Information

Study References

There are no available Study References

Data Source: ClinicalTrials.gov

Date Processed: April 03, 2020

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