Expired Study
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Cleveland, Ohio 44106


Purpose:

High blood pressure is one of the most common health problems in the United States. Genetic variations may cause some people to be more susceptible to developing high blood pressure. This study will identify variations in genes known to play a part in the development of high blood pressure.


Study summary:

High blood pressure affects nearly one third of all individuals in the United States. It is especially common in African Americans, with more than 40% of African Americans diagnosed with this condition. High blood pressure usually develops earlier in life and is more severe in African Americans than in other racial or ethnic groups. Many factors can cause high blood pressure, including stress, diet, diabetes, kidney disease, or obesity. Previous studies have also shown that genetic variations on two regions of chromosomes 6 and 21 may predispose some people to develop high blood pressure. Admixture mapping is a type of genetic analysis that aims to identify disease-causing genetic variations across different populations of people. Using admixture mapping, this study will examine previously collected genetic samples from African American participants in the Family Blood Pressure Program (FBPP) study and from African American, Mexican American, Nigerian, and Jamaican participants enrolled in other clinical studies. Study researchers will analyze the samples to identify and characterize genetic variations that are associated with an increased risk of high blood pressure in the African American population, as well as other racial and ethnic groups.


Criteria:

Inclusion Criteria: - Participated in the FBPP study (African American [800 people with high blood pressure and 800 control group participants] and Mexican American participants) - Participated in the American Family Study (African American participants) - Participated in the Phenotyping Study (African American, Nigerian, and Jamaican participants)


Study is Available At:


Original ID:

1415


NCT ID:

NCT00549991


Secondary ID:

R01HL086718


Study Acronym:


Brief Title:

Analyzing Genes That May Increase the Risk of Developing High Blood Pressure


Official Title:

Fine Mapping of Hypertension Genes Detected by Admixture Mapping in the FBPP


Overall Status:

Completed


Study Phase:

N/A


Genders:

Both


Minimum Age:

21 Years


Maximum Age:

N/A


Quick Facts

Healthy Volunteers
Oversight Has DMC
Study Is FDA Regulated
Study Is Section 801
Has Expanded Access

Study Source:

Case Western Reserve University


Oversight Authority:

United States: Federal Government


Reasons Why Stopped:


Study Type:

Observational


Study Design:

Observational Model: Case-Only, Time Perspective:


Number of Arms:

0


Number of Groups:

1


Total Enrollment:

8687


Enrollment Type:

Actual


Overall Contact Information

Official Name:Xiaofeng Zhu, PhD
Principal Investigator
Case Western Reserve University

Study Dates

Start Date:August 2007
Completion Date:June 2012
Completion Type:Actual
Verification Date:April 2009
Last Changed Date:November 26, 2013
First Received Date:October 24, 2007

Study Outcomes

Outcome Type:Primary Outcome
Measure:Genetic variations
Time Frame:Measured through admixture mapping genetic analysis
Safety Issues:False

Study Interventions

There are no available Study Interventions

Study Arms

There are no available Study Arms

Study Agencies

Agency Class:Other
Agency Type:Lead Sponsor
Agency Name:Case Western Reserve University
Agency Class:NIH
Agency Type:Collaborator
Agency Name:National Heart, Lung, and Blood Institute (NHLBI)

Samples and Retentions

Sample Retention:Samples With DNA
Description: Whole blood
Study Population: Previously collected genetic samples from African American participants in the Family Blood Pressure Program (FBPP) study and from African American, Mexican American, Nigerian, and Jamaican participants enrolled in other clinical studies will be examined.
Sample Method:Probability Sample

Study References

There are no available Study References

Data Source: ClinicalTrials.gov

Date Processed: January 21, 2020

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