Expired Study
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Nashville, Tennessee 37232


Purpose:

We are collecting brain tissue specimens and blood samples from patients at Vanderbilt University Medical Center who are undergoing intracranial surgery to remove brain tissue, including brain tumors, tissue from epilepsy surgery and brain tissue removed during surgery for other non-cancerous types of brain tissus. These specimens will then be studied using a novel microscopic laser-directed protein mass spectrometric analysis, looking for unique protein signatures.


Study summary:

We are collecting brain tissue specimens and blood samples from patients at Vanderbilt University Medical Center who are undergoing intracranial surgery to remove brain tissue, including brain tumors, tissue from epilepsy surgery and brain tissue removed during surgery for other non-cancerous types of brain tissus. These specimens will then be studied using a novel microscopic laser-directed protein mass spectrometric analysis. Data from different brain tissues including tumors of different histological sub-types will be analyzed for unique protein signatures. These protein signatures will then be statistically correlated with clinical data including time to tumor progression and response to therapy. The goal of this study is to determine molecular patterns that will be more predictive of tumor behavior, thus leading to an improved understanding of the basic biology of these poorly understood cancers. This in turn, may lead to more refined therapies and improved outcomes.


Criteria:

Inclusion Criteria: - A diagnosis of brain tumor or other non-cancerous tissue and are considered candidates fro a surgical procedure to biopsy or remove the brain tumor or other tissue type at Vanderbilt University Medical Center. - Age 2 to 85 Exclusion Criteria: - Patient or guardian that is unable to understand the informed consent process.


Study is Available At:


Original ID:

030258


NCT ID:

NCT00592709


Secondary ID:


Study Acronym:


Brief Title:

Analysis of Brain Tumors Using Matrix Assisted Laser Desorption/Ionization Mass Spectrometry


Official Title:

Analysis of Brain Tumors Using Matrix Assisted Laser Desorption/Ionization Mass Spectrometry


Overall Status:

Completed


Study Phase:

N/A


Genders:

N/A


Minimum Age:

2 Years


Maximum Age:

85 Years


Quick Facts

Healthy Volunteers
Oversight Has DMC
Study Is FDA Regulated
Study Is Section 801
Has Expanded Access

Study Source:

Vanderbilt University Medical Center


Oversight Authority:

United States: Institutional Review Board


Reasons Why Stopped:


Study Type:

Observational


Study Design:


Number of Arms:

0


Number of Groups:

0


Total Enrollment:

84


Enrollment Type:

Actual


Overall Contact Information

Official Name:Reid C. Thompson, MD
Principal Investigator
Vanderbilt University Medical Center, Department of Neurological Surgery

Study Dates

Start Date:May 2003
Completion Date:December 2012
Completion Type:Actual
Primary Completion Date:December 2010
Primary Completion Type:Actual
Verification Date:January 2019
Last Changed Date:January 9, 2019
First Received Date:January 2, 2008

Study Outcomes

Outcome Type:Primary Outcome
Measure:measurement of proteomic signatures in brain tumor samples
Time Frame:immediately upon analysis of the sample
Safety Issues:False

Study Interventions

There are no available Study Interventions

Study Arms

There are no available Study Arms

Study Agencies

Agency Class:Other
Agency Type:Lead Sponsor
Agency Name:Vanderbilt University Medical Center

Samples and Retentions

Sample Retention:Samples With DNA
Description: Brain Tissue
Study Population: Age 2 years through Age 85 years old
Sample Method:Non-Probability Sample

Study References

There are no available Study References

Data Source: ClinicalTrials.gov

Date Processed: January 21, 2020

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