Germline Genetic Variation and Risk of Chromosome Aberrations Among Mayak Nuclear Workers

Purpose:

RATIONALE: Collecting and studying samples of blood from workers exposed to high doses of radiation may help the study of cancer in the future. PURPOSE: This clinical trial is studying gene changes and risk factors in nuclear workers in Mayak, Russia.

Study summary:

OBJECTIVES: - Assess genetic polymorphism contribution in stable chromosome aberration frequency in nuclear workers in Mayak, Russia exposed to high-doses of radiation. OUTLINE: This is a multicenter study. Blood samples are collected annually during routine medical exams to assess intermediate biomarkers of radiation exposure. Samples are analyzed by mBAND biodosimetry and mFISH to measure intrachromosomal aberrations. Germline genetic variation in DNA repair and other genes is also assessed as a risk factor for chromosomal aberration frequency. Participants complete a short questionnaire assessing their jobs, as well as history of family health, smoking and alcohol consumption, and benign tumors, if any. Additional information is obtained from participants' medical records.

Criteria:

DISEASE CHARACTERISTICS: - Meets one of the following criteria: - Nuclear worker in Mayak, Russia who has had notable and atypical radiation exposure - Employed from 1948 to 1972 in 1 of 3 Ozyorsk plants directly related to nuclear weapon production - Remains a local resident - Estimates of external gamma dose and internal plutonium exposure available - Workers who did not have any plutonium exposure are still eligible due to their external radiation exposure - Current or former worker in auxiliary plant (water treatment plant or mechanical repair plant) at the Mayak facility - Cancer-free - No Tartars or Bashkirs PATIENT CHARACTERISTICS: - See Disease Characteristics PRIOR CONCURRENT THERAPY: - No radiation therapy or blood transfusion within the past year

Study is Available At:

Original ID:

CDR0000551642

NCT ID:

NCT01338168

Secondary ID:

NCI-04-C-N215

Study Acronym:

Brief Title:

Gene Changes and Risk Factors in Nuclear Workers in Mayak, Russia

Official Title:

Germline Genetic Variation and Risk of Chromosome Aberrations Among Mayak Nuclear Workers

ClinicalTrials.gov Link:

http://clinicaltrials.gov/show/NCT01338168

Overall Status:

Recruiting

Study Phase:

N/A

Genders:

Both

Minimum Age:

N/A

Maximum Age:

N/A

Study Source:

National Cancer Institute (NCI)

Oversight Authority:

There was an error processing this request

Reasons Why Stopped:

Study Type:

Observational

Study Design:

N/A

Number of Arms:

0

Number of Groups:

0

Total Enrollment:

357

Enrollment Type:

Anticipated

Data Source: ClinicalTrials.gov

Date Processed: March 21, 2023

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