Syracuse, New York 13210


Purpose:

The standard treatment for patients with Non-Small Cell Lung Cancer (NSCLC) and clinically negative lymph nodes remains surgery per current guidelines. Five year survival for patients with stage I non-small cell lung cancer is generally greater than 50% after surgery. Many of these patients have heart and lung issues or other diseases which keep them from undergoing curative surgery. Studies have shown that majority of these patients die from their cancer and not from their other diseases. This is the reason for treating early stage lung cancer patients with definitive therapy, when they cannot have surgery. This study will enroll twelve subjects to evaluate the side effects of this treatment, and decide if it is a good option for the patients that cannot have surgery.


Study summary:

Lung cancer is the leading cause of cancer related deaths for both men and women in the United States. In 2014 the estimated number of new lung cancer cases in the United States is 224,210. Approximately 159,260 people are estimated to die from lung cancer in 2014. Non-small cell lung cancer (NSCLC) constitutes 80% of all lung cancer cases. The standard treatment for patients with NSCLC and clinically negative lymph nodes remains surgery per NCCN guidelines. Five year survival for patients with stage I non-small cell lung cancer is generally greater than 50% after surgical resection with lobectomy. A significant number of these patients have cardio-pulmonary or other co-morbidities which preclude them from undergoing curative surgery. Studies have shown that majority of these patients die from their cancer and not from their co-morbidities. This forms the rationale for treating medically inoperable early stage lung cancer patients with definitive therapy. Treatment with radiotherapy (RT) has been the standard option for patients unable to undergo surgery. Radiation alone leads to slightly better outcomes but still not equivalent to surgery with 60-70% local failure with conventional fractionated radiotherapy over several weeks. The development of three-dimensional conformal radiotherapy (3DCRT) has allowed for more focused treatment while avoiding nearby normal tissue resulting in improved disease specific survival but overall survival is still poor. There is currently no data supporting the use of chemotherapy in the medically inoperable group either in an adjuvant setting or concurrently with RT in those with early stage lung cancer. In patients with unresectable Stage IIIA and IIIB NSCLC, combined chemo-RT has been proven to be superior to RT alone. Two randomized studies that compared concurrent versus sequential chemo-radiotherapy found that the concurrent approach provides superior outcomes. However this approach has not been studied in early stage lung cancer in the medically inoperable group. The medically inoperable patient cohort often does not undergo surgical staging, which increases the odds that they harbor occult regional disease. Chemotherapy given concurrently with radiation will act as a radiosensitizer and improve local disease control and could decrease rate of distant metastases. It is possible that the medically inoperable population also experience more side effects due to their co-morbidities and poor performance status. Hence there is a need to determine if concurrent chemoradiation is feasible and tolerable in the medically inoperable patients. The main side effect associated with concurrent chemoradiation in stage III NSCLC is esophagitis. This arises due to effect of radiation therapy to the regional lymph node (LN). The investigators' study population with early stage lung cancer has no nodal involvement. Hence, the investigators do not anticipate esophagitis being a major side effect in the researchers' study. There is recent data for adjuvant chemotherapy in the medically operable group. Data from the Lung Adjuvant Cisplatin Evaluation (LACE) showed with a median follow-up time of 5.2 years, the overall HR of death was 0.89 (95% CI, 0.82 to 0.96; P = .005), corresponding to a 5-year absolute benefit of 5.4% from chemotherapy. A similar trial evaluating the role of sequential chemotherapy after stereotactic body radiation therapy (SBRT) in the medically inoperable population was attempted at the investigators' institution but was closed due to poor accrual. Hence, the investigators are looking at the role of concurrent chemo-RT in this population.


Criteria:

Inclusion Criteria: - Pathologically or cytologically proven diagnosis of non-small cell lung carcinoma. - Solitary [T1bN0M0, T2aN0M0, T2bN0M0] lesion measuring 2-7cm in size. Staging is per AJCC 7th edition of TNM classification. - Patient must meet criteria for receipt of hypofractionated radiation therapy - Medically inoperable pulmonary status, cardiac status, or other serious co-morbidity, or patient refusal of primary surgery for lung cancer. - ECOG Performance status of 0-2. - Patients may have prior treatment for lung cancer based on the following criteria: 1. Surgical resection is allowed if surgery was > 12 months ago. 2. Patients treated with prior radiation are eligible if radiation was > 12 months ago and there is no evidence of progression and if the lesion is in a different lobe. 3. Prior chemotherapy if > 18 months ago Exclusion Criteria: - Node positive or metastatic disease. - Other active malignancy (specifically, risk of recurrence in 3 years estimated to be greater than 50%) except for non-melanoma skin cancer, in-situ cervical carcinoma (CIN), or low-risk prostate carcinoma on active surveillance are to be excluded. - Inability to receive systemic therapy or radiation therapy per protocol. - Inability to fulfill requirements of the protocol. - Any co-morbidity or condition which, in the opinion of the investigator, may interfere with the assessments and procedures of this protocol.


Study is Available At:


Original ID:

665895


NCT ID:

NCT02619448


Secondary ID:


Study Acronym:


Brief Title:

Concurrent Chemotherapy Plus HFR Radiation Therapy in Inoperable NSCLC


Official Title:

Pilot Study of the Safety and Feasibility of Administering Concurrent Chemotherapy and Accelerated Hypofractionated Radiation Therapy in the Treatment of Medically Inoperable T2A-T4 N0 Non-small Cell Lung Cancer.


Overall Status:

Recruiting


Study Phase:

N/A


Genders:

N/A


Minimum Age:

18 Years


Maximum Age:

N/A


Quick Facts

Healthy Volunteers
Oversight Has DMC
Study Is FDA Regulated
Study Is Section 801
Has Expanded Access

Study Source:

State University of New York - Upstate Medical University


Oversight Authority:

United States: Institutional Review Board


Reasons Why Stopped:


Study Type:

Interventional


Study Design:


Number of Arms:

1


Number of Groups:

0


Total Enrollment:

12


Enrollment Type:

Anticipated


Overall Contact Information

Official Name:Michael Mix, MD
Principal Investigator
State University of New York - Upstate Medical University
Primary Contact:Erin Bingham, BS
3154643603
binghame@upstate.edu
Backup Contact:Sherice Simpson, MS
3154645934
simpsons@upstate.edu

Study Dates

Start Date:December 2014
Completion Date:December 2025
Completion Type:Anticipated
Primary Completion Date:December 2023
Primary Completion Type:Anticipated
Verification Date:May 2018
Last Changed Date:May 1, 2018
First Received Date:March 16, 2015

Study Outcomes

Outcome Type:Secondary Outcome
Measure:Overall survival as determined by patient contact
Time Frame:24 months
Safety Issues:False
Outcome Type:Secondary Outcome
Measure:Time to overall progressions as measured by PET/CT
Time Frame:24 months
Safety Issues:False
Outcome Type:Secondary Outcome
Measure:Distant progression as measured by PET/CT
Time Frame:24 months
Safety Issues:False
Outcome Type:Secondary Outcome
Measure:Regional progression as measured by PET/CT
Time Frame:24 months
Safety Issues:False
Outcome Type:Secondary Outcome
Measure:Local progression as measured by PET/CT
Time Frame:24 months
Safety Issues:False
Outcome Type:Secondary Outcome
Measure:Radiographic response as measured by PET/CT
Time Frame:24 months
Safety Issues:False
Outcome Type:Primary Outcome
Measure:Toxicity as measured using the National Cancer Institute's Common Terminology Criteria for Adverse Events
Time Frame:24 months
Safety Issues:False
Description:Specifically grade 3+ toxicity associated with the treatment will be summarized by grade and type.

Study Interventions

Intervention Type:Drug
Name:Carboplatin
Description:chemotherapy
Arm Name:Chemotherapy with hypofractionated RT
Other Name:Paraplatin
Intervention Type:Drug
Name:Paclitaxel
Description:chemotherapy
Arm Name:Chemotherapy with hypofractionated RT
Other Name:taxol
Intervention Type:Radiation
Name:70 Gy in 20 fractions over 4 weeks
Description:accelerated hypofractionated RT
Arm Name:Chemotherapy with hypofractionated RT

Study Arms

Study Arm Type:Experimental
Arm Name:Chemotherapy with hypofractionated RT
Description:Carboplatin AUC 2 + Paclitaxel 50 mg/m2 given weekly x 4 concurrently with radiation therapy (70 Gy in 20 fractions) over 4 weeks

Study Agencies

Agency Class:Other
Agency Type:Lead Sponsor
Agency Name:State University of New York - Upstate Medical University

Sample and Retention Information

There are no available Sample and Retention Information

Study References

There are no available Study References

Data Source: ClinicalTrials.gov

Date Processed: January 21, 2020

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