Bethesda, Maryland 20892

  • Bipolar Disorder


This study looks to identify genes that may affect a person's chances of developing bipolar disorder (BP) and related conditions.

Study summary:

Bipolar affective disorder is a severe, heritable condition affecting about one percent of the population. The mode of inheritance is poorly understood and probably involves multiple loci of small to moderate effect. In this project, we use genetic mapping and sequencing methods to identify genetic markers and variations that contribute to the risk of bipolar disorder. Individuals diagnosed with bipolar disorder are studied, along with their relatives. Phenotypic information obtained from clinical interviews and family history is correlated with genotypic information obtained from genetic marker and sequencing methods. The goal is to identify genes involved in bipolar disorder and related conditions so that better methods of diagnosis, treatment, and prevention can be developed.


- INCLUSION CRITERIA: Age > 18 yr Able to provide informed consent Bipolar disorder or related conditions not attributable to substance abuse, neurological disease; or a 1st or 2nd degree relative of an enrolled participant. Related conditions are defined as those found more often among relatives of people with bipolar disorder or which have been shown to be genetically correlated with bipolar disorder through molecular genetic studies. These include major depression, schizophrenia, panic disorder, and attention deficit hyperactivity disorder. Able to safely provide a blood or saliva sample EXCLUSION CRITERIA: Active alcohol or substance abuse. NIMH employees/staff and their immediate family members will be excluded from the study per NIMH policy.



Primary Contact:

Principal Investigator
Francis J McMahon, M.D.
National Institute of Mental Health (NIMH)

Emily Besancon
Phone: (866) 644-4363

Backup Contact:

Francis J McMahon, M.D.
Phone: (301) 451-4455

Location Contact:

Bethesda, Maryland 20892
United States

For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)
Phone: 800-411-1222

Site Status: Recruiting

Data Source:

Date Processed: November 27, 2022

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