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New Orleans, Louisiana 70119


To evaluate topical A-007 in patients with advanced malignancies including Kaposi's sarcoma and lymphoproliferative disorders.


Inclusion Criteria Concurrent Medication: Allowed: - Maintenance antihormones, hormones, and glucocorticoids. Patients must have: - Histologically proven metastatic cancer including Kaposi's sarcoma and lymphoproliferative disorders to the skin or cutaneous sites. NOTE: - Primary basal or squamous cell cancer of the skin is allowed. - Failed both primary and secondary chemotherapy and/or immunotherapy protocols. - Measurable skin or cutaneous lesions. 4 Life expectancy of at least 20 weeks. Prior Medication: Required: - Prior therapy for cutaneous lesions from Kaposi's sarcoma or lymphoproliferative disorders. Allowed: - Prior maintenance steroids and hormone/antihormone therapy. Exclusion Criteria Co-existing Condition: Patients with the following symptoms or conditions are excluded: - Active infections other than medically stable HIV infection. - Active congestive heart failure, any persistent arrhythmia or transient serious arrhythmia (ventricular tachycardia, sinoatrial arrest, etc.), or progressive cardiomyopathy. - Unstable blood pressure. - Seizures or other CNS disorders. - Severe unstable diabetes mellitus. - Coagulopathies. - Thrombotic disease. - Any other medical conditions that would prevent completion of study or produce significant risk to patient. Concurrent Medication: Excluded: - Concomitant chemotherapy or immunotherapy. - Ongoing corticosteroid therapy (unless maintenance). Patients with the following prior conditions are excluded: - History of active cardiopulmonary or respiratory disease. - History of sun hypersensitivity and photosensitive dermatoses. - History of allergy or hypersensitivity to cosmetics, toiletries, or other dermatological products.



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New Orleans, Louisiana 70119
United States

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Site Status: N/A

Data Source: ClinicalTrials.gov

Date Processed: November 18, 2019

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