Expired Study
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Pittsburgh, Pennsylvania 15213


The purpose of this study is to test the effectiveness of Combivir plus abacavir plus 141W94 in patients who previously have used anti-HIV drugs.

Study summary:

In this open-label study antiretroviral-experienced patients receive Combivir (3TC/AZT tablet) plus 1592U89 (abacavir) and 141W94 twice daily for 48 weeks.


Inclusion Criteria Patients must have: - CD4 count greater than 50 cells/mm3. - HIV RNA less than 50,000 copies/ml. - No active AIDS (excluding CD4 count less than 200 cells/mm3). - Ability to comply with dosing schedule and protocol evaluations. Prior Medication: Allowed: AZT or non-nucleoside reverse transcriptase inhibitors (NNRTIs). Exclusion Criteria Co-existing Condition: Patients with any of the following symptoms or conditions are excluded: - Active AIDS (not excluding CD4 count less than 200). - Malabsorption syndrome affecting drug absorption. - Serious medical condition that would compromise safety of the patient. Concurrent Medication: Excluded: - AZT or NNRTIs. - More than 1 week treatment with any protease inhibitor. - Enrollment in any other investigational drug protocol. Patients with the following prior conditions are excluded: History of clinically relevant pancreatitis or hepatitis within the past 6 months. Required: Antiretroviral therapy with either single or double reverse transcriptase inhibitors.



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Location Contact:

Pittsburgh, Pennsylvania 15213
United States

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Site Status: N/A

Data Source: ClinicalTrials.gov

Date Processed: November 18, 2019

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