Expired Study
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New York, New York 10021


To determine safety and tolerance of administering aerosolized recombinant interferon gamma (IFN-gamma) for 4 weeks in patients with AIDS. To examine activation of alveolar macrophages by aerosolized IFN-gamma administration. To determine if subcutaneous (SC) injection of IFN-gamma can activate alveolar macrophages in AIDS patients.


Inclusion Criteria Patients must have: - Diagnosis of AIDS with one or more opportunistic infections. - Kaposi's sarcoma with prior history of opportunistic infection. - Stable dose of zidovudine (AZT) therapy. - Preserved pulmonary, renal and hepatic function. Exclusion Criteria Co-existing Condition: Patients with the following conditions or symptoms are excluded: - Presence of active infection. - Active opportunistic infections. - Cardiac disease. - Central nervous system disorders. - History of seizures. - Irreversible airway disease. Patients with the following are excluded: - Co-existing conditions and symptoms listed in Patient Exclusion Co-existing Conditions. Prior Medication: Excluded within 4 weeks of study entry: - Immunosuppressive therapy. - Cytotoxic therapy. - Excluded: - Interferon gamma therapy.



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New York, New York 10021
United States

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Site Status: N/A

Data Source: ClinicalTrials.gov

Date Processed: October 09, 2019

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