Expired Study
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Wilmington, Delaware 19899


Purpose:

RATIONALE: Analyzing the structure of genes found in a person's cancer cells may help doctors improve methods of treating patients with colon cancer. PURPOSE: Clinical trial to study the genes of patients treated with chemotherapy for colon cancer.


Study summary:

OBJECTIVES: - Determine the relationship between disease free survival, overall survival, and tumor replication error status for patients who have received adjuvant chemotherapy for colon cancer on CALGB protocol 8896. - Determine the prognostic and predictive values for response to this therapy in these patients. OUTLINE: Samples of tumor and normal tissue are obtained from CALGB 8896 patients. The samples are tested for somatic mutations and tumor replication error (RER) tumor status. Patients do not receive the results of the genetic testing and the results do not influence the type or duration of treatment. PROJECTED ACCRUAL: At least 300 specimens will be accrued for this study.


Criteria:

DISEASE CHARACTERISTICS: - Patients who received chemotherapy for colon cancer as part of CALGB protocol 8896 - Underwent an initial resection for adenocarcinoma of the colon and were determined to have a high risk of tumor recurrence based upon nodal disease or local extension of tumor with obstruction or perforation due to tumor - Surgical specimen blocks available, including tumor tissue and normal tissue PATIENT CHARACTERISTICS: Age: - Not specified Performance status: - Not specified Life expectancy: - Not specified Hematopoietic: - Not specified Hepatic: - Not specified Renal: - Not specified PRIOR CONCURRENT THERAPY: Biologic therapy: - Not specified Chemotherapy: - See Disease Characteristics Endocrine therapy: - Not specified Radiotherapy: - Not specified Surgery: - See Disease Characteristics


NCT ID:

NCT00003571


Primary Contact:

Study Chair
Monica M. Bertagnolli, MD
Dana-Farber/Brigham and Women's Cancer Center


Backup Contact:

N/A


Location Contact:

Wilmington, Delaware 19899
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: November 18, 2019

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