Philadelphia, Pennsylvania 19107

  • Turner's Syndrome


RATIONALE: Turner's syndrome is a disease in which females are missing all or part of one X chromosome and do not produce estrogen. Giving estrogen is standard treatment for girls who have Turner's syndrome. Estrogen may be effective treatment for mental and social functioning problems experienced by girls with Turner's syndrome. PURPOSE: Clinical trial to study the effectiveness of long term estrogen therapy on mental and social functioning in girls who have Turner's syndrome.

Study summary:

PROTOCOL OUTLINE: Participants are evaluated for cognitive and social function at entry and 4 years following entry. Assessments include the Wechsler Intelligence Scale for Children-Revised, a child behavior checklist, the Children's Self-Concept Scale, and visual-spatial, visual-motor, attention, memory, language, and facial recognition tasks. Patients (and parents) undergo X-chromosome analysis; brain magnetic imaging is optional. Controls are matched using school selection and telephone interviews. A study duration of 12 years is estimated.


PROTOCOL ENTRY CRITERIA: - Girls aged 8 and 12 years with Turner's syndrome-compatible karyotype - Age-matched girls without Turner's syndrome entered as controls - Concurrent registration on Thomas Jefferson University growth study required of subjects with Turner's syndrome



Primary Contact:

Study Chair
Judith Levine Ross
Jefferson Medical College of Thomas Jefferson University

Backup Contact:


Location Contact:

Philadelphia, Pennsylvania 19107
United States

There is no listed contact information for this specific location.

Site Status: N/A

Data Source:

Date Processed: June 16, 2021

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