Rahway, New Jersey 07065

  • HIV Infections


The purpose of this study is to see if it is safe and effective to give L-743,872 to patients with thrush, an AIDS-related yeast infection of the mouth, that has not been cured with fluconazole treatment.

Study summary:

Patients are randomized to treatment with L-743,872 at one of two doses administered intravenously by a peripheral line once-daily. Patients are treated for 48 hours beyond resolution of symptoms or for a maximum of 14 days. Each patient is expected to complete the study, including the 14-day follow-up, within approximately 4 weeks. A physical examination is performed daily during the antifungal treatment period and at the follow-up visits 7 and 14 days post-therapy. Laboratory tests of blood and urine for safety are performed every three days during treatment and at follow-up 7 days post-therapy. Liver enzymes are drawn at the 14-day follow-up visit.


Inclusion Criteria You may be eligible for this study if you: - Have thrush that has not responded to fluconazole treatment. - Are 18-65 years old.



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Location Contact:

Rahway, New Jersey 07065
United States

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Site Status: N/A

Data Source: ClinicalTrials.gov

Date Processed: April 03, 2020

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