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Seattle, Washington 98195

  • Postoperative Pain


This trial will test the effectiveness of amitriptyline in relieving chronic pain of adults that have had an amputation

Study summary:

This double-masked placebo controlled trial will randomize patients (n=125) who are 6 months or more after amputation and have a 3 or more month history of pain to a daily dose of amitriptyline or a placebo for 6 weeks. Patients will receive a complete functional neurological examination by one of the study physicians or nurses masked to their treatment assignment. Study participants will also be interviewed by telephone to assess pain, pain interference with activities, physical and mental health, and number of health care visits for pain, at the beginning and end of the six-week trial and four months later.


Inclusion Criteria: - Amputation six months ago or longer - Pain for 3 months or longer Exclusion Criteria: - History of cardiovascular disease, seizures, or glaucoma - Currently taking antidepressant medications - Currently hyperthyroid or taking thyroid medication - Currently pregnant



Primary Contact:

Principal Investigator
Lawrence Robinson, MD, Professor
University of Washington, Department of Rehabilitation

Backup Contact:


Location Contact:

Seattle, Washington 98195
United States

There is no listed contact information for this specific location.

Site Status: N/A

Data Source:

Date Processed: April 03, 2020

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