Expired Study
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Cincinnati, Ohio 45229


OBJECTIVES: I. Determine the role of magnesium deficiency in the pathogenesis of decreased serum vitamin D and reduced bone density in children with chronic cholestatic liver disease.

Study summary:

PROTOCOL OUTLINE: Patients receive magnesium sulfate IV over 1 hour on day 3. Patients then receive oral magnesium gluconate supplementation daily. Treatment with magnesium sulfate repeats once at 3-6 months.


PROTOCOL ENTRY CRITERIA: --Disease Characteristics-- - Diagnosis of liver disease with chronic cholestasis Nonsyndromic intrahepatic cholestasis Alagille's syndrome Extrahepatic biliary atresia - Direct bilirubin greater than 2 mg/dL OR Bile acids greater than 20 micromoles/L - No hepatic decompensation defined as one or more of the following: Ascites Peripheral edema PT at least 4 seconds longer than control Albumin less than 3 g/dL --Patient Characteristics-- - Renal: No significant renal disease - Cardiovascular: No significant cardiovascular disease - Pulmonary: No significant pulmonary disease



Primary Contact:

Study Chair
James Heubi
Children's Hospital Medical Center, Cincinnati

Backup Contact:


Location Contact:

Cincinnati, Ohio 45229
United States

There is no listed contact information for this specific location.

Site Status: N/A

Data Source: ClinicalTrials.gov

Date Processed: October 09, 2019

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