Los Angeles, California 90095

  • Thymoma and Thymic Carcinoma


RATIONALE: Radiofrequency ablation uses high-frequency electric current to kill tumor cells. CT-guided radiofrequency ablation may be effective treatment for lung cancer. PURPOSE: Phase II trial to study the effectiveness of radiofrequency ablation in treating patients who have refractory or advanced lung cancer.

Study summary:

OBJECTIVES: - Determine the safety and toxicity of radiofrequency ablation in patients with refractory or advanced pulmonary malignancies. - Determine the efficacy of this treatment, in terms of local control, in these patients. - Determine whether CT scan is a reasonable imaging assessment tool for treatment delivery and follow-up in these patients. OUTLINE: Patients undergo percutaneous CT-guided radiofrequency ablation directly to the tumor over 2 hours. Patients are followed at 1, 3, 6, and 12 months. PROJECTED ACCRUAL: A total of 30 patients will be accrued for this study.


Inclusion Criteria: - Diagnosis of a primary or secondary intrathoracic malignancy - Any cell type or origin - Involving the intrapulmonary, mediastinal, or pleural/chest wall - Inoperable primary or metastatic cancer to the lung - Refractory to or not amenable to conventional therapy (e.g., surgery, chemotherapy, or radiotherapy) - Single or multiple lesions that are non-contiguous with vital structures or organs such as: - Trachea - Heart - Aorta - Great vessels - Esophagus - Less than 5 cm in largest dimension - Accessible via percutaneous transthoracic route - Hepatic: - Coagulation profile normal



Primary Contact:

Study Chair
Robert D. Suh, MD
Jonsson Comprehensive Cancer Center

Backup Contact:


Location Contact:

Los Angeles, California 90095
United States

There is no listed contact information for this specific location.

Site Status: N/A

Data Source: ClinicalTrials.gov

Date Processed: April 03, 2020

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