Expired Study
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Houston, Texas 77030


This is a dose-escalation study to determine the maximum tolerated dose and toxic effects of clofarabine in patients with chronic lymphocytic leukemia and other acute leukemias. Clofarabine is a synthesized hybrid nucleoside analog, which is believed to possess the better qualities of fludarabine and chlorodeoxyadenosine, the 2 most active agents against lymphoproliferative disorders. Thus, it is hoped that this drug will be more active and less toxic than similar drugs.

Study summary:

The first group of patients will be treated at the starting dose level of 2 mg/m2 over 1 hour daily for 5 days. Dosage escalation will be permitted in individual patients if no toxicity occurred during the preceding course. Subsequent dose escalations will be by 50% until Grade 2 toxicity, then by 35% until the maximum tolerated dose. Completion date provided represents the completion date of the grant per OOPD records


Inclusion criteria: - Diagnosis of chronic lymphocytic leukemia - Diagnosis of other acute leukemia - At least 2 weeks since prior chemotherapy, immunotherapy, and/or radiotherapy - Recovered from toxic effects of prior therapy - Bilirubin no greater than 2 mg/dL - Creatinine no greater than 1.5 mg/dL Exclusion criteria: - Candidate for treatment of higher efficacy or priority - Pregnant or nursing



Primary Contact:

Principal Investigator
Hagop M. Kantarjian, M.D.
M.D. Anderson Cancer Center

Backup Contact:


Location Contact:

Houston, Texas 77030
United States

There is no listed contact information for this specific location.

Site Status: N/A

Data Source: ClinicalTrials.gov

Date Processed: October 09, 2019

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