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St. Louis, Missouri 63110


A double-blind, randomized, dose-response study of four dilutions of Dryvax in previously vaccinated adults in order to assess the clinical success rates, humoral responses, and virus-specific actifity of cytotoxi T cells and interferon-y producing T cells


Inclusion Criteria: - For cohort E (never vaccinated): Aged 18-31; Never been vaccinated for smallpox. - If female, not pregnant or lactating. - Promise to use an effective method of birth control for 7 months after vaccination. - Negative result on a test for HIV, AIDS, Hepatitis B and C. - Acceptable as blood donors. - For cohorts A, B, C, D (previously vaccinated): Aged 32 to 60 years; known history of smallpox vaccination with a typical vaccinia scar; no smallpox vaccination after 1971. - Healthy adults (aged 18-60). Exclusion Criteria: - Eczema or history of eczema, or other chronic skin disorder. - Pregnancy or lactation. - History of immunodeficiency, liver disease, severe kidney impairment, malignancy, HIV, Hepatitis B, or Hepatitis C. - Household contact with persons who are under 12 months of age, pregnant or lactating, or have any of the specified diseases.



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St. Louis, Missouri 63110
United States

There is no listed contact information for this specific location.

Site Status: N/A

Data Source: ClinicalTrials.gov

Date Processed: November 18, 2019

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