Houston, Texas 77030

  • Chronic Lymphocytic Leukemia


The purpose of this study is to determine the side effects and antitumor response of patients with lymphoid malignancies to Deoxycoformycin (DCF)/Pentostatin.

Study summary:

Deoxycoformycin(DCF)/Pentostatin is a T-cell cytotoxic drug with previously reported responses in lymphoid malignancies but larger studies are needed.


Inclusion Criteria: - Histologic proof of lymphoid malignancy with an expected complete response rate of less than 20 percent OR have failed at least one prior therapy. - No chemotherapy within 3 weeks of entry into study and must have recovered from acute toxic effects of prior therapy. - Life expectancy of at least 12 weeks. - Performance status equal to or less than Zubrod 2. - Signed informed consent. - Patients with measurable disease. - Age at least 16 years. - Adequate bone marrow function (unless involvement of bone marrow by lymphoma) defined as AGC greater than 1500 and platelet count greater than 100,000. - Adequate hepatic function with a bilirubin less than or equal to 1.5 mg % and SGPT less than or equal to 4 times the upper limits of normal. - Adequate renal function defined as serum creatine less than or equal to 1.5 mg %. Exclusion Criteria: - No serious intercurrent illness. - Adequate contraception (if applicable). - NO patients with significant cardiac disease, i.e. New York Heart Association (NYHA) class III or IV. - NO experimental clinical trial within 3 weeks of study entry. - NO patients with active CNS disease. - Full recovery from any prior surgical treatment. - NO active active infections.



Primary Contact:

Principal Investigator
Razelle Kurzrock, MD
MD Anderson

Backup Contact:


Location Contact:

Houston, Texas 77030
United States

There is no listed contact information for this specific location.

Site Status: N/A

Data Source: ClinicalTrials.gov

Date Processed: April 03, 2020

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