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Omaha, Nebraska 68105


The purpose of this study is to test the use of time-released bupropion (Wellbutrin) in patients receiving treatment for alcohol abuse/dependence as an aid to stop smoking. Patients will receive either a time-released bupropion or placebo. Both groups will receive nicotine replacement therapy during the 9 week study. A final followup assessment will be conducted 6 months from the start of treatment.


Inclusion Criteria: - Currently a patient in the Omaha VA Medical Center, Substance Abuse Treatment Center (SATC) or at Catholic Charities Campus for Hope. - Have a diagnosis of alcohol abuse or alcohol dependence. - Smoke 20 or more cigarettes/day (may also smoke pipes/cigars). - Be interested in quitting smoking. - Provide name, addresses, and phone numbers of at least two individuals who can provide information on their alcohol, nicotine, and other drug use during the follow-up period. - If female, patient must a) be of non-childbearing potential, b) have a negative pregnancy test, c) sign a document stating they do not plan on becoming pregnant during the study. - Agree to sign informed consent. - Able to read and understand study-related forms and procedures. Exclusion Criteria: - Advanced cardiac, pulmonary, renal, or liver disease. - History of seizures. - History of brain tumor or significant head trauma. - History of bulimia or anorexia nervosa. - Current major depressive disorder or past history of panic disorders, schizophrenia, or bipolar affective disorder. - Using psychoactive drugs. - Receiving treatment with medications that lower seizure thresholds. - Use of an investigational drug in any study in the past four weeks. - Currently using any asthma medication. - Used time-released bupropion in the past 12 months. - Currently using any other treatments to stop smoking.



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Omaha, Nebraska 68105
United States

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Site Status: N/A

Data Source: ClinicalTrials.gov

Date Processed: October 09, 2019

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