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Pittsburgh, Pennsylvania 15213

  • Panic Disorder


This 6-month study, with a 3-month follow up period, will compare the effectiveness of new and traditional psychotherapies for depression with panic or anxiety symptoms.

Study summary:

Many depressed patients also experience significant symptoms of panic or anxiety. This study will compare the effectiveness of a new therapy called interpersonal psychotherapy for depression with panic or anxiety symptoms (IPT-PS) with that of traditional interpersonal psychotherapy for depression (IPT). Participants are randomly assigned to receive up to 24 weeks of treatment with either IPT-PS or traditional IPT. Improvements in interpersonal functioning, quality of life, and symptoms of depression and anxiety will be assessed at the end of therapy and at a 3-month follow-up.


Inclusion Criteria: - DSM-IV diagnosis of major depression with co-existing panic or anxiety symptoms. Exclusion Criteria: - History of manic episode(s). Patients who have had hypomanic episodes in the past will be accepted into the study, provided they meet other admission criteria and are not presenting in a current hypomanic or mixed episode. - History of schizophrenia or schizoaffective disorder. - Organic affective syndrome. - Unspecified functional psychosis. - Anorexia nervosa or bulimia nervosa. Patients meeting criteria for an eating disorder not otherwise specified will not be excluded. - Chronic drug or alcohol abuse/dependence within the past 2 years. Patients with abuse related to episodes will not be excluded. - DSM-IV criteria for borderline or antisocial personality disorder. Patients who meet criteria for other Axis II disorders will not be excluded. - Inpatient treatment due to suicide risk or psychotic symptoms. - Index episode secondary to the effect of medically prescribed drugs. - Significant or untreated medical illness, including cardiovascular disorder, renal or liver disease, epilepsy, untreated hypertension, or unstabilized endocrine disease. - Medical illness that would interfere with the best treatment strategy for the potential participant. - Current treatment with an antidepressant. Patients on a stable dose of anxiolytics for at least 3 months prior to study participation who are able to maintain this dosage throughout the study will not be excluded. - Pregnant and breast-feeding women will be accepted into the study, but will not be prescribed adjunctive medications.



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Pittsburgh, Pennsylvania 15213
United States

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Site Status: N/A

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Date Processed: March 26, 2020

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