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Kansas City, Kansas 66160


The purpose of this pilot study is to examine the effects of combined pharmacotherapy (Zyban/NRT)/behavioral treatment on smoking cessation among methadone maintenance therapy patients.

Study summary:

This is a one-arm, open label pilot study of MMT patients to determine whether bupropion, nicotine replacement therapy, and behavioral counseling is a feasible and potentially effective intervention for smoking cessation. The smoking behaviors of participants will be be followed for 6 months post quit-date to determine effect-size estimates for a future, large scale trial.


Inclusion Criteria: - Patients in long-term methadone maintenance treatment - Patient smokes at least 10 cigarettes per day, are stable on their use of methadone (phase 2 or higher treatment), smoked for at least 1 year, be willing to participate for 6 months, and not have used bupropion or nicotine replacement therapy for 6 months Exclusion Criteria: - Patients who use prescription drug regimens that might affect methadone or bupropion metabolism - Patients with cardiovascular disease, asthma, COPD - Patients who are pregnant or breastfeeding - Patients with regular use of alcohol, other illicit drugs, or other types of tobacco (chewing or pipe for example)



Primary Contact:

Principal Investigator
Kimber Richter, Ph.D.
University of Kansas Medical Center

Backup Contact:


Location Contact:

Kansas City, Kansas 66160
United States

There is no listed contact information for this specific location.

Site Status: N/A

Data Source: ClinicalTrials.gov

Date Processed: October 09, 2019

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