Expired Study
This study is not currently recruiting Study Participants on ClinicalConnection.com. If you would like to find active studies please search for clinical trials.

Los Angeles, California 90024


The purpose of this study is to determine whether the anti-inflammatory drug celecoxib can delay the onset of Alzheimer Disease (AD) in people with Age Associated Memory Impairment (AAMI). This study will also evaluate genetic risk and brain structure as potential predictors of mental decline.

Study summary:

AD is one of the most common mental disorders of late life. Preliminary studies indicate that anti-inflammatory drugs may attenuate or prevent AD symptoms, but efficacy trials are needed. Participants in this study will be randomly assigned to receive either celecoxib or placebo for 18 months. Participants will undergo positron emission tomography (PET) and magnetic resonance imaging (MRI) scans of the brain. Routine laboratory blood tests, cognitive tests, and an electrocardiogram (ECG) will be performed. Participants will also be screened for Parkinson disease. Follow-up testing will be conducted at specific intervals following the study.


Inclusion Criteria: - NIMH diagnostic criteria for Age Associated Memory Impairment (AAMI) - Mini-Mental State Examination (MMSE) score between 26 and 30 (unless < 8 years of educational achievement) - No significant cerebrovascular disease - Estrogen replacement therapy and thyroid replacement therapy (if the participant is euthyroid) are permitted if the therapies are stable for > 1 month - Memory and verbal fluency cut-off scores that increase the probability of incipient dementia (Buschke-Fuld: 34; verbal fluency: 46 for letters, 7 for categories; Benton Visual Retention: 5) - Adequate visual and auditory acuity to allow neuropsychological testing - Normal screening laboratory tests and electrocardiogram (ECG) Exclusion Criteria: - Possible or probable Alzheimer Disease (AD) or other dementia - Neurologic or other physical illness that could produce cognitive deterioration - History of transient ischemic attacks (TIAs), carotid bruits, or lacunes on an MRI scan - History of myocardial infarction within the previous year or unstable cardiac disease - Uncontrolled hypertension (systolic BP > 170 or diastolic BP > 100) - History of significant liver disease, pulmonary disease, diabetes, or cancer - DSM-IV criteria for major psychiatric disorders within the previous 2 years - Past or present history of alcoholism or drug dependence - Untreated depression as determined by a Hamilton Depression Rating Scale (HAM-D) score of 12 or more - Drugs that may significantly affect psychometric test results - Centrally active beta-blockers, narcotics, clonidine, anti-Parkinsonian medications, antipsychotics, benzodiazepines, systemic corticosteroids, medications with significant cholinergic or anticholinergic effects, anti-convulsants, warfarin, vitamins other than the standard multivitamin supplement, ginkgo biloba, and any nutraceuticals. Occasional chloral hydrate use will be allowed, but discouraged, for insomnia. - Investigational drugs within the previous month or longer, depending on drug half-life - Contraindication for MRI scan (e.g., metal in body, claustrophobia)



Primary Contact:


Backup Contact:


Location Contact:

Los Angeles, California 90024
United States

There is no listed contact information for this specific location.

Site Status: N/A

Data Source: ClinicalTrials.gov

Date Processed: November 18, 2019

Modifications to this listing: Only selected fields are shown, please use the link below to view all information about this clinical trial.

Click to view Full Listing

This study is not currently recruiting Study Participants on ClinicalConnection.com. The form below is not enabled.