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Philadelphia, Pennsylvania 19104


The goal of this study is to use single photon emission computed tomography (SPECT) and functional magnetic resonance imaging (f-MRI) of the brain to study the response of both normal participants and participants with Osteoarthritis (OA) of the knee to acupuncture.

Study summary:

Recent experimental studies in both animal and humans have begun to demonstrate some measurable physiologic effects that are associated with acupuncture, suggesting the possibility of a neurophysiologic explanation. In addition, brain research continues to uncover a complex set of endogenous neurologic control systems, such that it has become clear that the brain plays a major role in the modulation of pain perception and control. If acupuncture can be demonstrated to have a consistent effect on specific areas of the brain, it will become possible to explore the potential efficacy of acupuncture based on measurable neurophysiologic responses.


Inclusion criteria: - Seen in an outpatient clinical setting - Have active knee OA of >6 months including Kellgren x-ray changes >2 from an x-ray report <12 months old or new x-ray interpretation - Moderate unilateral only pain (average >4/10 on a 0-10 likert scale) for more than 5 out of 7 days - Have the capacity to understand the requirements of the study and complete the baseline studies in a reasonable time frame, as determined by the interviewer Exclusion criteria: - Having had acupuncture before (must be acupuncture naïve) - Any history of claustrophobia that could affect the subject's ability to tolerate the f-MRI study - Hip or ankle disease by history or exam severe enough to cause pain >2/10 daily - Bleeding disorder or current use of warfarin or heparin by patient history - Other primary causes of chronic knee pain, per the referring physician, including chondromalacia patella, torn meniscus or ligament injury.



Primary Contact:

Principal Investigator
John T. Farrar, MD, MSCE
University of Pennsylvania

Backup Contact:


Location Contact:

Philadelphia, Pennsylvania 19104
United States

There is no listed contact information for this specific location.

Site Status: N/A

Data Source: ClinicalTrials.gov

Date Processed: October 09, 2019

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