Expired Study
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North Charleston, South Carolina 29406


Purpose:

The purpose of this study is to learn whether treating individuals with Alzheimer's disease and depression with the anti-depressant medication sertraline (Zoloft) is helpful to people with Alzheimer's disease and to their families and caregivers.


Study summary:

Participants are randomly assigned to treatment with sertraline (range 25-125 mg per day) or identical placebo for 24 weeks. There are 8 scheduled in-person visits in the 24 weeks. Visits include neuropsychological testing. Caregivers are asked to are the patient on a Daily Affect Diary for 6 weeks during the study period. Telephone followup is done at weeks 36 and 48. Both groups receive caregiver support/education.


Criteria:

Inclusion: - Ability of the participant, caregiver or surrogate to provide written informed consent. - Dementia due to Alzheimer's disease - Stable treatment for Alzheimer's disease - Ability for the participant's caregiver to accompany the participant to study visits and participate in the study. Exclusion - Presence of a brain disease that might otherwise explain the presence of dementia - Clinically significant hallucinations or delusions - Current treatment of antipsychotics, anticonvulsants, and other antidepressants, benzodiazepines, or other psychotropic medications - Need for hospitalization or residence in a nursing facility


NCT ID:

NCT00086138


Primary Contact:

Study Chair
Constantine G. Lyketsos, MD, MHS
Johns Hopkins University


Backup Contact:

N/A


Location Contact:

North Charleston, South Carolina 29406
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: January 21, 2020

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