Expired Study
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Louisville, Kentucky 40202


The purpose of this study is to assess whether children with moderate to severe bronchiolitis treated with standard racemic epinephrine therapy via 70:30 helium-oxygen (heliox) driven nebulization will have improvements in measurements of airway more rapidly than those treated with conventional air-oxygen driven nebulization.


Inclusion Criteria: - Any child 2-12 months old seen in the emergency department. - A clinical bronchiolitis score > 3 by modified Wood's Clinical Bronchiolitis Score (M-WCBS). - Diagnostic criteria of bronchiolitis includes tachypnea, cough, prolonged expiratory phase, wheezing, rales, chest retractions, and hyperinflation of lungs on chest radiograph. After consenting a patient to the study, respiratory syncytial virus (RSV) infection will be tested by rapid enzyme-linked immunoabsorbent assay of nasal secretions. Exclusion Criteria: - No child will be excluded based on race or gender - Patients under the age of 2 months or greater than 12 months - Patients with cyanotic heart disease - Patients with lobar pneumonia, defined by results of chest radiographs. - The presence of interstitial disease or diffuse patchy marking consistent with atelectasis on chest radiographs will not exclude patients. - Patients with croup. - Patients with foreign body aspiration. - Patients with history of cystic fibrosis, bronchopulmonary dysplasia or other chronic lung disease. - Patients with liver or renal disease. - Patients with sickle cell anemia. - Patients requiring mechanical ventilation. - Patients who develop supraventricular tachycardia secondary to racemic epinephrine administration. - Patients with tracheomalacia or bronchomalacia. - Patients who had received bronchodilators within 2 hours of initiation of the study. - Patients who had received systemic corticosteroids within 72 hours of enrollment - Patients who suffered from persistent airway hyperreactivity in the 3 months before the study. - Patients who do not tolerate the nasal cannulae for 45 out of 60 minutes.



Primary Contact:

Principal Investigator
In K Kim, MD
University of Louisville, Dept. of Pediatrics, Div. of Pediatric Emergency Medicine

Backup Contact:


Location Contact:

Louisville, Kentucky 40202
United States

There is no listed contact information for this specific location.

Site Status: N/A

Data Source: ClinicalTrials.gov

Date Processed: October 09, 2019

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