Expired Study
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Seattle, Washington 98109


Purpose:

RATIONALE: Chemoprotective agents may protect normal cells from the side effects of chemotherapy. Ice chips or saline mouth rinse may lessen the severity or help prevent symptoms of mucositis or mouth sores in patients receiving melphalan and autologous stem cell transplant for multiple myeloma. It is not yet known whether ice chips are more effective than saline mouth rinse in reducing or preventing mucositis. PURPOSE: This randomized phase III trial is studying ice chips to see how well they work compared to saline mouth rinse in reducing or preventing mucositis in patients receiving melphalan and autologous stem cell transplant for multiple myeloma.


Study summary:

OBJECTIVES: - Compare the efficacy of administering ice chips vs room temperature normal saline oral rinse before, during, and after melphalan administration, in terms of reducing or eliminating grade 3 or 4 oral mucositis, in patients undergoing autologous peripheral blood stem cell transplantation (PBSCT) for multiple myeloma. - Compare the number of days that IV narcotic therapy is required for oral mucositis pain in patients treated with these regimens. - Compare the use of IV hydration and/or total parenteral nutrition after autologous PBSCT in patients treated with these regimens. - Compare overall quality of life, in terms of ability to eat food and drink liquids, in patients treated with these regimens. OUTLINE: This is a randomized, pilot study. Patients are stratified according to age (less than 60 years vs 60 years and over). Patients are randomized to 1 of 2 treatment arms. - Arm I: Patients receive oral ice chips 15 minutes before, during, and for 8 hours after melphalan infusion* on day -2. - Arm II: Patients receive room temperature normal saline oral rinses over 30 seconds 15 minutes before, during, and for 8 hours after melphalan infusion* on day -2. All patients undergo autologous peripheral blood stem cell transplantation (PBSCT)* on day 0. NOTE: *Patients receive melphalan infusion and undergo autologous PBSCT on protocol FHCRC-1137.00. Quality of life is assessed 3 days a week for 4 weeks. After completion of study treatment, patients are followed for 28 days and then periodically thereafter. PROJECTED ACCRUAL: A total of 40 patients (20 per treatment arm) will be accrued for this study within 18 months.


Criteria:

DISEASE CHARACTERISTICS: - Diagnosis of multiple myeloma - Scheduled to undergo an autologous peripheral blood stem cell transplantation (PBSCT) for multiple myeloma on protocol FHCRC-1137.00 - Scheduled to receive a regimen of single-agent melphalan at a dose of 200 mg/m^2 before PBSCT PATIENT CHARACTERISTICS: Age - Over 18 Performance status - Not specified Life expectancy - Not specified Hematopoietic - Not specified Hepatic - Not specified Renal - Not specified PRIOR CONCURRENT THERAPY: Biologic therapy - See Disease Characteristics Chemotherapy - See Disease Characteristics Endocrine therapy - Not specified Radiotherapy - Not specified Surgery - Not specified Other - No concurrent artificial saliva on the day of melphalan infusion (day -2)


NCT ID:

NCT00118339


Primary Contact:

Principal Investigator
William I. Bensinger, MD
Fred Hutchinson Cancer Research Center


Backup Contact:

N/A


Location Contact:

Seattle, Washington 98109
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: June 25, 2018

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