New York, New York 10021

  • Hodgkin's

Purpose:

Primary Objective: - To determine the toxicity profile and tolerability of alemtuzumab (Campath) when administered in combination with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) chemotherapy (C-CHOP) in patients with T-cell, null-cell and NK-cell lymphomas. Secondary Objectives: - To evaluate response rate, overall survival, and disease-free survival in patients with T-cell, null-cell, and NK-cell lymphomas treated with Campath + CHOP chemotherapy. - To assess the incidence of cytomegalovirus (CMV) reactivation in patients with these lymphomas treated with the Campath + CHOP combination. - To determine features which might be predictive of resistance to treatment or predictive of relapse, including the absence of glycosylphosphatidylinositol (GPI)-linked proteins.


Criteria:

Inclusion Criteria: - Patients must have a diagnosis of non-B-cell, non-Hodgkin's lymphoma (including T-cell, null-cell, or NK-cell lymphoma, but excluding lymphoblastic lymphoma) - Stage II, III, or IV disease requiring chemotherapy - At least one site of measurable disease, 1.5 cm in diameter or greater - Age > or = 18 years - Absolute granulocyte count of at least 1500 cells/mm3, unless neutropenia is due to marrow infiltration by the tumor - Platelet count of at least 100,000 cells/mm3 unless thrombocytopenia is due to marrow infiltration by tumor - Creatinine less than 2 x upper limits of normal (ULN) - Total bilirubin less than 2 x ULN (dose reduced vincristine and adriamycin required for bilirubin > 1.2 mg/dL) - Echocardiogram (Echo) or multiple gate acquisition scan (MUGA) documenting a normal ejection fraction prior to chemotherapy - Able to give informed consent Exclusion Criteria: - Known central nervous system (CNS) involvement - Known HIV disease - Patients who are pregnant or nursing - Any factor which might limit the patient's ability to provide informed consent - Life expectancy < 3 months - Patients who are unwilling to agree to use an effective means of birth control while on treatment


NCT ID:

NCT00161590


Primary Contact:

Principal Investigator
Richard Furman, MD
Weill Medical College of Cornell University


Backup Contact:

N/A


Location Contact:

New York, New York 10021
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: April 03, 2020

Modifications to this listing: Only selected fields are shown, please use the link below to view all information about this clinical trial.


Click to view Full Listing

This study is not currently recruiting Study Participants on ClinicalConnection.com. The form below is not enabled.