Rochester, New York 14642


The purpose of the research study is to evaluate an automated, laser-based technique for measuring DNA damage caused by radiation during cancer treatment in immature red blood cells.

Study summary:

Correlative studies: analysis of RT effect on genotoxicity by assessing cytogenetic changes (dicentrics), micronucleated lymphocytes (MN-lymph), and micronucleated reticulocytes (MN-RET) using peripheral blood of patients receiving radiation. i) document the kinetics by which radiation-induced MN-RET enter the peripheral blood stream. ii) benchmark the MN-RET endpoint against current gold-standard biodosimetry endpoints—dicentrics and MN-lymphocytes. iii) measure inter-individual variation in baseline and radiation-induced MN-RET frequencies. iv) in collaboration with several FCM-equipped laboratories, evaluate the transferability of the human MN-RET scoring assay.


Inclusion Criteria: - Patients that are scheduled to begin radiotherapy to the large-field chest region are eligible if: - Daily radiation dose is between 1.8 and 5 Gy/day - Any single dimension of field size is ≥ 15 cm - Provision of written informed consent or - Or patients receiving IMRT or Tomotherapy, when low-dose radiation is spread out to the normal tissues, irrespective of daily radiation doses. - Or patients receiving radionucleotides as part of the medical treatment (cancer or non-malignant conditions) - Or patients who will receive diagnostic CT scans, PET/CT scans, mammograms, or diagnostic imaging requiring radionucleotides



Primary Contact:

Principal Investigator
Yuhchyau Chen, MD, Ph.D
Universtiy of Rochester, Dept of Radiation Oncology

Therese Smudzin, BS
Phone: 585-275-7848

Backup Contact:

Yuhchyau Chen, MD, Ph.D
Phone: 585-275-5623

Location Contact:

Rochester, New York 14642
United States

Yuhchayau Chen, MD, Ph.D.

Site Status: Recruiting

Data Source:

Date Processed: November 18, 2019

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