Jamaica Plain, Massachusetts 02130

  • Schizophrenia

Purpose:

This study will examine the physical response to clozapine or chlorpromazine in people with schizophrenia that has not improved with treatment.


Study summary:

This is a longitudinal double-blind 12-week study of the clinical and biochemical response to clozapine or chlorpromazine in a group of treatment-refractory schizophrenic patients. The study has 4 phases: (1) A recruitment period; (2) a period of discontinuation of psychotropic medication; (3) a drug-washout period; and (4) a 12-week double-blind trial of clozapine or chlorpromazine.


Criteria:

Inclusion Criteria: - 19-60 years of age - Diagnosis of schizophrenia - BPRS score > 50 - Clinical Global Impressions rating > 4 - One of the following: BPRS items rated greater than or equal to 4, conceptual disorganization, suspiciousness, hallucinations, unusual thought content. - At least 2 six-week trials of different neuroleptics given at a dosage equivalent to at least 600 mg per day of chlorpromazine OR at least 1 eight-week trial of a neuroleptic given at a dosage equivalent to at least 800 mg per day of chlorpromazine. - The patient (or the patient's authorized legal representative) must understand the nature of the study and sign the informed consent. Exclusion Criteria: - History of substance dependence within the past 2 months - Major medical problems precluding the use of clozapine - Pregnancy or lactation - A serious suicide/homicide risk


NCT ID:

NCT00169039


Primary Contact:

Principal Investigator
Alan I Green, MD
Harvard Medical School


Backup Contact:

N/A


Location Contact:

Jamaica Plain, Massachusetts 02130
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: April 03, 2020

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