Expired Study
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Bridgewater, New Jersey 08807


Purpose:

The trial will compare the efficacy and safety of concomitant chemoradiation with tirapazamine, cisplatin and radiation versus cisplatin and radiation.


Criteria:

Inclusion Criteria: - Previously untreated squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx, or larynx. - Stage III or IV disease (excluding T1N1, and T2N1 and metastatic disease). - ECOG performance status less than or equal to 2. - Absolute neutrophil count at least 1.5 X 10^9/L, platelet count at least 100 X 10^9/L, and hemoglobin > 9g/dL. - Serum bilirubin < 1.25 times ULN and AST/ALT < 2.5 times ULN. - Calculated creatinine clearance (Cockcroft-Gault) > 55 mL/min. Exclusion Criteria: - Metastatic Disease - Primary cancers of the nasal and paranasal cavities and of the nasopharynx - Significant intercurrent illness that will interfere with the Chemotherapy or Radiation Therapy during the trial - Symptomatic peripheral neuropathy > grade 2 - Clinically significant hearing impairment - Significant cardiac disease


NCT ID:

NCT00174837


Primary Contact:

Study Director
ICD CSD
Sanofi-Aventis


Backup Contact:

N/A


Location Contact:

Bridgewater, New Jersey 08807
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: October 09, 2019

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